Clinical Medicine (Theses and Dissertations): Recent submissions
Now showing items 221-240 of 355
-
Investigation of the role of RACKI in T lymphocyte migration
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012)Induction of the innmune response and production of pro-inflammatory cytokines results in the upregulation of ICAM-1 expressed on endothelial cells. Binding of ICAM-1 to the β2 integrin receptor LFA-1 on T cells induces T ... -
Microcrack distributions in bone : effects of stress and bone mineral density
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)The work is divided into four main sections. Chapter 2 it was performed compression and bending tests, with the use of a dye sequence technique. The tests were carried out to detect and measure microdamage development after ... -
The role of inflammation and macrophage accumulation in the development of obesity induced Type 2 diabetes mellitus and the possible therapeutic effects of long chain n-3 polyunsaturated fatty acids
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)Obesity gives rise to a state of chronic, low-grade inflammation characterised by inflamed white adipose tissue (WAT) with increased infiltration of macrophages termed adipose tissue macrophages (ATM). These ATM produce ... -
Investigation of ABO blood group expresser phenotype
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)The aims of this project were to study the variability of the ABO blood group expression on human platelets and to explore the underlying molecular mechanisms. 541 Irish blood donors were studied. The recently described ... -
Genetic and environmental risk factors in age-related macular degeneration in vitro, in vivo and population studies
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)The aims of this project are to show the potential sites of interaction between underlying genetic susceptibilities and environmental influences (cigarette smoke) in neovascular AMD. Our current hypothesis proposes that ... -
Clinical, metabolic and biochemical responses to a diet and aerobic excercise intervention in early-onset type 2 diabetes mellitus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2013)This study was a longitudinal, randomised, controlled trial. Two primary groups of subjects were recruited for comparison: young obese patients (less than 30 years of age) with early- onset type 2 diabetes (YT2), and a ... -
Syphilis and HIV co-infection in Dublin; strategies to enhance diagnosis, investigation and management
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Following historically low levels of reported cases of syphilis in Dublin in the 1990s there was a large outbreak of syphilis reported in 2001. Numerous interventions were implemented and the rates again decreased in 2003. ... -
Increased von Willebrand Factor clearance in the pathogenesis of von Willebrand disease and the role of von Willebrand Factor glycans in modulating susceptibility to clearance in-vivo
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Von Willebrand Factor (VWF) is a multimeric, adhesive, plasma glycoprotein which plays two important roles in haemostasis, first as a carrier for the procoagulant factor VIII (FVIII) and second, as a bridge between platelets ... -
Role of von Willebrand factor glycans in modulating susceptibility to ADAMTS13 proteolysis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Von Willebrand factor (VWF) is a large plasma sialoglycoprotein that mediates platelet tethering at sites of vascular injury. VWF adhesive function is dependent upon multimeric composition, which is regulated in plasma by ... -
Assessment of platelet activation and function in symptomatic and asymptomatic carotid stenosis, ischaemic stroke and transient ischaemic attack
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012)Aims: The purpose of this thesis was to comprehensively assess the levels of platelet activation, platelet function and platelet turnover in patients with moderate or severe asymptomatic or symptomatic carotid artery ... -
Assessing brain and cognitive function in multiple sclerosis cross-sectionally and longitudinally with multimodal methods : insights form high-density electrophysiology, neuropsychological examination and magnetic resonance imaging
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012)Cognitive impairment (CI) affects up to 65% of multiple sclerosis (MS) patients and can occur in the absence of physical disability (Hoffmann, Tittgemeyer, & von Cramon, 2007). MS is the most common chronic inflammatory ... -
Defining the mechanism of protection of the class 1 Allele HLA-A *03 in a single source outbreak of Hepatitis C Virus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Hepatitis C virus infects approximately 180 million persons worldwide and results in serious liver disease. Significant obstacles have hindered efforts to design an effective vaccine; in particular these include the profound ... -
The pathogenic role of macrophage migration inhibitory factor in high-fat diet induced insulin resistance
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012)Adipose tissue inflammation is central to the pathogenesis of obesity associated insulin resistance (IR), type 2 diabetes mellitus (T2DM) and hepatic steatosis. High-fat diet (HFD)-induced adipose tissue expansion is ... -
Environmental conditions can have a profound effect on the trajectory of disease in the maflg(ft)/maflg(ft) model of skin barrier deficiency and atopic dermatitis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012)The prevalence of atopic disease has increased in recent decades. The hygiene hypothesis postulates that cleaner environments contribute to this observed increase in atopy. The cutaneous manifestations of atopic dermatitis ... -
Molecular mechanisms of resistance to therapeutic MEK inhibition in BRAF [V600E] cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2013)Aberrant activation of the mitogen activated protein kinase (MAPK) pathway is common in solid tumours. This hierarchical pathway consists of a three-tiered kinase casade of BRAF, MAPK kinase (MEK1/2) and the extracellular ... -
The epidermal growth factor (EGFR) in non-small cell lung cancer (NSCLC) : biomarker and therapeutic target
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)Extract from Introduction: Lung cancer is the leading cause of cancer death in industrialized nations (Parkin, Bray et al. 2005). With approximately 1.35 million people diagnosed with the disease worldwide each year, and ... -
Characterization of the outer membrane vesicles of the gastric pathogen Helicobacter pylori
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)The aim of the present study was to investigate the structure and composition of H. pylori outer membrane vesicles (OMVs) and to functionally characterize several OMV-associated pathogenic activities. Initial studies ... -
The role of inflammatory mediators and hypoxia in lung carcinogenesis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2009)Lung cancer is the most common cause of cancer related death in Ireland. While treatment options and long term survival have increased for other cancer types, lung cancer lags behind in both areas, with 5 year survival ... -
Management of maternal HIV-1 infection in pregnancy : the experience of the GUIDE clinic
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2009)As of the end of 2007 there were an estimated 33.2 (30.6-36.1) million people worldwide living with HIV-1 or AIDS. Almost seven thousand new infections occurred ever day in 2007. Children under 15 years of age accounted ... -
Obesity, insulin resistance and Type 2 Diabetes in young Irish people
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)The epidemic of obesity in Irish youth, one of the highest ranking internationally, represents a major threat to public health. However, little is known of the metabolic and clinical characteristics of this cohort. I ...
