Clinical Medicine (Theses and Dissertations): Recent submissions
Now showing items 241-260 of 355
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Association of clinical phenotype and genetic burden in coeliac disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)Coeliac disease (CD) is a chronic small intestinal immune-mediated enteropathy precipitated by exposure to a gluten containing diet in genetically predisposed individuals. The clinical presentation of CD is highly ... -
Novel Screening Strategies for HIV, Hepatitis B and C Infection
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)Abstract Title: Novel Screening Strategies for HIV, Hepatitis B and C Infection. Author: Dr Sarah O?Connell Introduction: Despite prevention measures in place, rates of HIV infection have failed to decline in Ireland in ... -
The clinical characterisation and genetic epidemiology of familial ALS in Ireland
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2013)The overall objective of this thesis is to collate the existing literature on familial ALS and to address shortcomings in the research, to investigate aggregation of ALS and other conditions among relatives of patients ... -
Multiparametric evaluation of magnetic nanoparticles for theranostic applications in breast and pancreatic cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2016)Magnetic iron oxide nanoparticles (MNP) are superparamagnetic below 30 nm in size, have high surface to volume ratio in the nanometre size range, display no remnant magnetism in the absence of a magnetic field yet have ... -
Investigation of cortical and sub-cortical processing of pressure pain transduction in healthy controls and chronic lumbar radicular pain pre and post oxycodone treatment-An event related fMRI study.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)Background: - Few scientific developments have been more striking than the ability to measure the activity of the functioning human brain. Experimental acute pain stimulus in healthy controls can predict with more than 90% ... -
The Environmental Epidemiology of Amyotrophic Lateral Sclerosis in Europe
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)Amyotrophic Lateral Sclerosis (ALS) is a terminal neuro-degenerative disorder of adults, typically having rapid progression and involving both motor and cognitive function. ALS exhibits considerable heterogeneity of both ... -
Physical activity level and barriers to physical activity among an adult type 1 diabetes population
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)Context: Information on physical activity (PA) levels and its association with glycaemic control and cardiovascular disease (CVD) risk is lacking among Irish adults with T1DM. Aims: (1) PA levels were assessed in this ... -
DIRECT ACTING ANTIVIRALS IN HEPATITIS C INFECTION: DEVELOPING A PERSONALISED MODEL OF CARE
Summary Hepatitis C infection (HCV) is a major global health problem. The HCV treatment landscape has changed beyond recognition in a few short years. The development of HCV direct acting antiviral therapy (DAA) has ... -
Investigating a role for TLR signalling and complement deposition in retinal degeneration
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)Age-related macular degeneration (AMD) and Retinitis Pigmentosa (RP) are the most common cause of progressive vision loss in the developed world. AMD is a multifactorial disease with both genetic and environmental risk ... -
Development of an optimised subharmonic dynamic contrast-enhanced ultrasound imaging technique for liver cancer
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)Dynamic Contrast-Enhanced Ultrasound (DCEUS) using ultrasound contrast agents (UCA) is a non-invasive method of imaging the microvasculature, typically employing harmonic imaging. Subharmonic imaging (SHI) detects signals ... -
The value of real world data in healthcare decision-making : practical applications using observational data from the National Hepatitis C Treatment Registry
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2017)Introduction: Observational research can play an integral role in the healthcare decision-making process. In an era of ever increasing drug costs, healthcare decision-makers are under pressure to optimally allocate resources. ... -
Nanomedicines for the treatment of coagulation disorders
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2016)Nanomaterials are becoming increasingly utilised in all areas of science, technology and healthcare. More specifically in terms of nanomedicine, the physical and chemical properties of the materials allow for application ... -
Deep phenotyping through biomarker profiling of frontotemporal dementia (FTD) with and without co-morbid motor neuron degeneration: A multidimensional approach
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)PhD Thesis abstract: Trinity College Dublin Title: Deep Phenotyping Through biomarker Profiling of Frontotemporal Dementia (FTD) With and Without Co-morbid Motor Neuron Degeneration: A Multidimensional Approach Authors: ... -
An evaluation of the quality of improvement potential of computer assisted screening technology within a cervical cancer screening programme
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)Between 2006 and 2011, three studies - known as CAESAR (Computer Assisted Evaluation, Screening And Reporting) were carried out to evaluate Computer Assisted Screening (CAS) with manual primary screening to current procedures ... -
A method for quantifying the absolute accuracy and precision of dynamic contrast enhanced MRI acquisition techniques
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)Introduction: Dynamic contrast enhanced (DCE) MRI, combined with pharmacokinetic (PK) modelling of the resulting data, has shown great promise for the detection, monitoring, and grading of prostate cancer. However, to ... -
Functional echocardiography in the preterm infant
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)From our research we have shown that myocardial function assessment using tissue Doppler derived strain, strain rate, torsion and fractional area change is both feasible and reliable. We applied these novel echocardiographic ... -
Vitamin D in ageing: an investigation into the role of vitamin D in cognitive and physical functioning in coummunity-dwelling older adults
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)With our growing older population, there is an increasing need to identify potentially modifiable characteristics or interventions that are intended to enhance the functioning of older adults who could be described as ... -
Therapeutic outcomes, immunological responses to treatment and vaccine preventative strategies for Hepatitis C in HIV seropositive individuals
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)Introduction: HIV and Hepatitis C virus (HCV) represent significant causes of morbidity and mortality worldwide. Because of shared routes of transmission co-infection is common. Recent advances in treatment for both ... -
Examining the breadth and burden of chronic kidney disease in community-dwelling older adults
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)Introduction: Chronic kidney disease (CKD), characterised by reductions in glomerular filtration rate (GFR), is associated with premature mortality and end stage kidney disease. Older adults have the highest prevalence of ... -
The role of monocytes in ANCA associated vascultis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)ANCA associated vasculitis (AAV) encompasses several autoimmune conditions characterised by destruction of small vessels, inflammation of the respiratory tract, and glomerulonephritis. Most patients harbour autoantibodies ...
