Clinical Medicine (Theses and Dissertations): Recent submissions
Now showing items 261-280 of 355
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Vaccination as a means of disease prevention in HIV infected individuals; successes, challenges & opportunities
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)This thesis is structured to systemically assess susceptibility to vaccine preventable infections in HIV-infected adults, to investigate effectiveness of an integrated vaccine programme as a model of care for vaccine ... -
Evaluation of neuroimaging biomarkers in amyotrophic lateral sclerosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative condition characterised by relentless upper and lower motor neuron degeneration. The clinical spectrum, symptoms onset, genetic vulnerability and ... -
Optimal use of immunomodulator and biological therapy in Inflammatory Bowel Disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)Loss of response (LOR) to anti-TNFa therapy is a significant problem, and leads to increased hospitalisation rates, surgical intervention, and steroid dependency. Loss of response is multifactorial. However there ... -
Macrophage immunometabolism in the host response to Mycobacterium tuberculosis infection
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)Tuberculosis (TB) is the leading infectious disease killer in the world, alongside HIV. Our understanding of the complex host immune response to Mycobacterium tuberculosis (Mtb) remains incomplete, but varied clinical ... -
An investigation of epigenetic effects in Atherosclerosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)Epigenetic mechanisms may explain some of the missing heritability associated with CVD and how external factors such as diet, environment and lifestyle contribute to disease development and progression. This thesis aimed ... -
Effects of bile acids and fatty acids on cell signalling in human colorectal cancer cells
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2005)Colorectal cancer is a multifactorial disease. The interplay between genetic and environmental factors leads to the development of CRC. There have been great advancements in the knowledge of genetic alterations leading to ... -
Novel mediators regulating innate and adaptive type 17 immune responses
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2014)The discovery of a third subset of T helper cells and more recently innate T cell subsets which preferentially express IL-17A has led to intensive investigation into the roles these cells play in both host defence and ... -
Aspects of muscle performance, mobility limitations, excercise interventions and cognitive functioning in older adults
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2014)In section A, two studies were conducted to systematically investigate and compare the cross sectional and longitudinal physiological determinants of the age-related loss of lower extremity muscle power in healthy and ... -
Adaption of the Functional Lumen Imaging Probe for non-radiological evaluation of the upper oesophageal sphincter
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2014)The aim of this research was to adapt the Functional Lumen Imaging Probe (FLIP), a novel non-radiological measurement tool, to measure upper oesophageal sphincter (DOS) distensibility and opening patterns during swallowing. ... -
Protein Kinase Cη : regulation of expression and functional role in human T lymphocytes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2014)Protein kinase Cη (PKCη) is a member of the novel PKC subfamily of serine/threonine kinases that has been shown to play critical roles in cell differentiation, proliferation, secretion and apoptosis in several cell types. ... -
The role of Ma1 in macrophage responses to tuberculosis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2015)Heterozygotes for the common S180L polymorphism in the TLR adaptor Mal (TIRAP) are protected from a number of infectious diseases, including tuberculosis (TB), whereas homozygotes are at increased risk. We report that Mal ... -
Biophysical and immunological pathway endophenotyping of atopic dermatitis stratified for filaggrin mutations
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2015)Atopic dermatitis (AD, eczema) is a common inflammatory skin disease, driven and modified by environmental, immunological and genetic factors. It is characterized clinically by inflammatory and pruritic skin lesions and ... -
Investigating the role of constitutively active truncated androgen receptor splice variants in prostate cancer
(Trinity College (Dublin, Ireland). School of Medicine, 2012)The androgen receptor (AR) is fundamental for the growth and survival of normal and malignant prostate cells. Therefore, androgen deprivation therapy remains the first‐line treatment for disseminated disease, however, ... -
The association between Fusobacterium nucleatum Outer Membrane Vesicles and Colonic Cancer
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)Fusobacterium nucleatum, a gram-negative spindle-shaped anaerobic bacterium, is a component of the human microbiome that primarily inhabits the oral cavity and is associated with many diseases, including sinusitis, ... -
Vitamin D in older adults and its relationship to cognition, blood pressure, mood and falls
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2014)An increasing body of evidence supports a role for vitamin D in cognition, blood pressure, mood and falls. Vitamin D deficiency is prevalent in older adults and might provide an alternative novel treatment strategy for ... -
Enternal nutrition in the community setting
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)The practice of tube feeding patients outside the acute hospital setting has existed in Ireland for over a decade. Anecdotal evidence (mainly from hospital dietitians) suggested that the care services for these patients ... -
Laser speckle correlation as a non-contact ocular microtremor measurement technique
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2014)Ocular microtremor (OMT) is high frequency, low amplitude fixational eye movement present in all healthy people. It occurs even while the eye appears to be at rest. Benefits of measuring OMT have been proven in a number ... -
Epidemiology of lung cancer in the Republic of Ireland
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2005)The study aimed at investigating the epidemiology of overall lung cancer pattern in the Republic of Ireland across different time-periods. The study also examined the lung cancer incidence pattern across major cell-types ... -
Interrogation of PI3K inhibition strategies in non-small cell lung cancer (NSCLC)
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2014)Lung cancer is the leading cause of cancer related death in Ireland and much of the Western world. Despite advances in anti-cancer therapies, the overall 5 year survival for lung cancer remains poor, at less than 15%. As ... -
Application of probabilistic modelling to food chemical exposure assessments
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2004)Risk assessment of food chemical intake is at the core of food safety policy within the EU and the assessment of food chemical exposure is an integral part of the risk assessment process. There is an increasing demand to ...
