Clinical Medicine (Theses and Dissertations): Recent submissions
Now showing items 281-300 of 355
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Particulate air pollution and mortality in Dublin 1980-1996
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2000)Air pollution in Dublin was studied for the period from 1980 to 1996. The factors which contribute to air pollution were investigated, and the nature of particulate air pollution is discussed. The trends in air pollution, ... -
Investigating protein and gene biomarker expression, specifically chemokine (C-X-C motif) ligand 16 (CXCL16), associated with cardiovascular diseases using a combination of in vitro and in vivo techniques
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2014)A patient based study was designed to analyze serum concentrations of 10 known inflammatory markers, GM-CSF, IFN-γ, IL-10, IL-12p70,IL-1β, IL-2, IL-6, IL-8, TNF-a and CXCL16 in asymptomatic and symptomatic pre-operative ... -
The role of HIF-lalpha and hypoxia in the preferential response of prostate tumours to microtubule-targeting agents
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)Tumour hypoxia is emerging as a common feature of prostate tumours associated with poor prognosis mainly due to their resistance to chemo- radiotherapy regimes. The efficacy of microtubule-targeting agents (MTAs) has ... -
Cytokine polymorphisms in the study of Helicobacter pylori related gastric pathology
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2005)Persistent local inflammation is now accepted as a risk factor in the development of a number of cancers. Non-cardia gastric cancer is thought to develop after a long lead-time whereby persistent inflammation, caused by ... -
An investigation of risk factors for fracture in patients with osteoporosis and osteopaenia using biomechanical, biochemical and radiological assessments
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Osteoporosis is defined as a skeletal disorder characterised by compromised bone strength resulting in an increased risk for fracture. Hip fractures are the most common osteoporotic fracture in older adults and occur due ... -
Biomechanical measures of function of the ano-rectal region of the human body
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2015)In this research, the Functional Lumen Imaging Probe (FLIP), a novel measurement tool, was adapted to measure the biomechanical properties and morphological changes of the ano-rectal region during distension and provocative ... -
High content analysis of cellular localisation and biocompatibility of CdTe and CdSe / ZnS nanoparticles
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)The rules governing particle properties at the nanoscale relate more to the laws of quantum mechanics than classical mechanics. Biologists have been keen to harness nanoparticles not only for these properties but also ... -
Investigations into the role of mast cell mediated effects on the intestinal epithelial barrier in vitro : implications for the pathogenesis of irritable bowel syndrome
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2013)Irritable bowel syndrome (IBS) is a highly prevalent functional bowel disorder characterised by abdominal pain or discomfort and associated with altered bowel habit, abdominal bloating and disturbed defecation. The aetiology ... -
Microtubule associated signal transduction processes in t-cell migration
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)The ordered, directional migration of T-lymphocytes is a key process during immune surveillance, and immune response. T-cell migration is a complex, highly coordinated process. This requires cell adhesion to the high ... -
Genetic studies in coeliac disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)This study is primarily concerned with elucidating genetic contributions to coeliac disease in the Irish population via case control based association studies. Due to the nature of complex diseases, and the large sample ... -
Investigation of lymph node transplantation as therapy for breast cancer related lymphedema
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2009)Humans have hundreds of lymph nodes, collections of which are found in the underarms, groin, neck, chest, and abdomen. They have long been considered 'neutral' elements in terms of lymph transport. An assumption has always ... -
Mechanisms of human innate immune cell death and consequent adaptive immune responses during Mycobacterium tuberculosis infection
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012)Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, is a highly successful pathogen, infecting an estimated one-third of the global population. Mtb infection leads to the deaths of approximately 1.3 ... -
Vitamin B12 in the elderly and its relationship to cognition, falls and balance, mood and mortality
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Observational studies to date have provided conflicting evidence with respect to the clinical relevance of vitamin B12 status in elderly patients. The aims of this work were to establish the relationship of vitamin B12 ... -
Ursodeoxycholic acid : a molecular modulator of the inflammation-carcinoma sequence in the oesophagus?
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012)Gastro-oesophageal reflux disease (GORD) is a prevalent disease, affecting up to 20% of the western population. In up to 10% of these patients Barrett’s Oesophagus (BO) will exist. This nietaplastic epithelium carries a ... -
Cytokine expression in coronary artery disease : high sensitivity detection in a patient cohort and analysis of its effect on cardiac myoblast cells in an in vitro model
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Cardiovascular disease has evolved into one of the major causes of death in the developed world. Common clinical presentations of the disease are Acute Coronary Syndromes (ACS), Heart Failure, Carotid disease, Abdominal ... -
Undernutrition in inactive and mildly active Crohn's Disease : an unrecognised problem?
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2009)Crohn's disease (CD), the incidence of which is increasing worldwide, is a chronic transmural inflammatory disease that can affect any part of the gastrointestinal tract. It follows a relapsing remitting course and results ... -
Genomic characterisation and comparative proteome analysis of Helicobacter pylori related gastroduodenal pathologies
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2009)The Gram-negative bacterium Helicobacter pylori is a gastric pathogen that chronically infects more than half the world’s population. H. pylori infection induces various upper gastro- duodenal diseases, and there is a ... -
Renal function, cardiovascular disease and long term outcome in different cohorts of the Glasgow population
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Over the past ten to fifteen years, the interaction between cardiovascular disease and chronic kidney disease (CKD) has come under increased scrutiny. Traditional cardiovascular risk factors are also associated with the ... -
Protein Kinase C : a key enzyme in mediating interferon-a signalling and a new player in its activity against Hepatitis C infection
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2013)The hepatitis C virus (HCV) is a major cause of chronic liver cirrhosis and hepatocellular carcinoma (Lauer and Walker, 2001). The World Health Organisation estimates that there are 170 million individuals infected globally, ... -
The role of novel risk markers in cardiovascular disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Cardiovascular disease (CVD) is the leading cause of death in Ireland and globally. Conventional risk factors such as blood pressure, cholesterol and smoking account for most of CVD. A small but significant residual risk ...
