Clinical Medicine (Theses and Dissertations): Recent submissions
Now showing items 301-320 of 355
-
Cutaneous changes in renal transplant recipients - is there a relationship between benign and malignant disease?
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2009)Renal transplant recipients are at an increased risk of many cutaneous diseases. The increased incidence of cutaneous malignancy is well recognised. Cutaneous infections and iatrogenic effects of immunosuppressive medications ... -
Cardiovascular risk in non-diabetes mellitus insulin resistant states
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012)This thesis explores the various cardiovascular risks that occur in insulin resistant states apart from type 2 diabetes mellitus (T2DM). Various cardiovascular risk markers and metabolic derangements related to cardiovascular ... -
Barrett's oesophagus and associated cancer : the influence of bile acid regulated genetic factors and intestinal transcription factors in the pathogenesis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012)Gastrooesophageal reflux disease (GORD) is very common and it is estimated that up to 20% of the western population will experience weekly heartburn. The initial simple mucosal damage can lead to further complications like ... -
Studies on methotrexate cytotoxicity and apoptosis in human B-lymphocyte cell lines : with emphasis on 5,10-methylenetetrahydrofolate reductase 677C→T genotype and folate status
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Methotrexate (Mtx) is an antifolate drug which is widely used in treatment of cancer and of autoimmune and inflammatory conditions. The main mechanism by which Mtx operates is inhibition of dihydrofolate reductase (DHFR), ... -
The role of insulin-like growth factor 1 receptor (IGF-IR) in non-small cell lung cancer (NSCLC)
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012)Lung cancer is the most common cause of cancer related death in Ireland and worldwide. Despite modest advances in traditional cytotoxic chemotherapy, survival rates remain disappointing at approximately 15%. Targeted ... -
Characterisation of nanoparticle distribution, intergrity and toxicity in vivo and in vitro using advanced spectroscopic and microscopic approaches
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012)Much uncertainty surrounds the potential toxicity of new engineered nanomaterials to human health and the environment, either during manufacture, use or at the end of their life cycle. The current generalised methodologies ... -
Ocular Microtremor as a clinical and scientific tool in neurologic disease : validation and application of a generalised discovery protocol
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Ocular microtremor (OMT) , a high frequency low amplitude eye movement, is one of three fixational eye movements present even when the eyes are apparently at rest. The tremor is thought to be related to tonic neural ... -
Vascular correlates of cognitive performance in a community based elderly population
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)Population studies suggest that cardiovascular risk factors may be associated with cognitive impairment. Epidemiological studies evaluating individual markers of vascular disease as a risk factor for cognitive dysfunction ... -
Type 2 diabetes, insulin resistance and effects of exercise in young adults
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)Study 1- Characteristics of the physically active but insulin resistant phenotype. Methods: Data from the European Group on Insulin Resistance- Relationship between Insulin Sensitivity and Cardiovascular Risk study was ... -
Bile acids and Barrett's oesophagus : the development of a functional siRNA screen to identify novel therapeutic targets
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)The development of oesophageal adenocarcinoma (OAC) occurs in a setting of chronic reflux known as gastro-oesophageal reflux disease (GORD) and with a recognised premalignant lesion, Barrett’s oesophagus (BO). BO is ... -
An investigation into novel components and signalling mechanisms of inflammasomes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)This thesis concerns an analysis of caspase-1 and ASC, key components of the inflammasome. At the outset Rab39a had been found in a complex with caspase-1. Rab39a is a member of the Rab GTPase family, a group of proteins ... -
Ocular microtremor measurement, characterization & analysis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)Ocular Microtremor (OMT) is a high frequency tremor of the eye present in all normal subjects even if the eye is apparently still. It is one of the fixational eye movements. Changes in the OMT frequency and pattern have ... -
An in vivo study of utricular hair cell degeneration and regeneration following animoglycoside induced damage of the mammalian inner ear
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2007)The anatomy of the mammalian ear is similar between the different subspecies. This applies to the structure of the utricle in humans and in guinea pigs. Hence the choice of the guinea pig utricle allows any findings ... -
The application of metabolomics to human nutrition research
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)Background: Recent developments in analytical technologies and bioinformatics are driving modem advances in biological research. Many of these methods will have particular relevance in the field of nutrition. Among these ... -
The effects of dietary fat and genotype on insulin sensitivity : the LIPGENE Dietary Intervention Study
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)The Metabolic Syndrome (MetS) is characterised by hyperinsulinaemia, low glucose tolerance, dyslipidaemia (increased triacylglycerol, (TAG) and non-esterified fatty acids (NEFA) and reduced high density lipoprotein ... -
C5L2, a nonsignalling C5A receptor is uncoupled to G proteins
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)The complement anaphylatoxins are prominent mediators of host defence and inflammation. The small subunit of the fifth component of complement, C5a has complex effects in vivo including potential anti- and pro-inflammatory ... -
Translating molecular approaches for the detection and evaluation of minimal residual disease kinetics in childhood acute lymphoblastic leukaemia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)Childhood acute lymphoblastic leukaemia (ALL) is the leading cause of cancer-linked mortality identified in children. Approximately 80% of patients are successfully treated. However, 20-25% of patients will still go on to ... -
Investigating novel targets of DNA methylation for the early detection of prostate cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2007)Prostate cancer is an escalating international health problem. It is the most common non- cutaneous malignancy and the second leading cause of cancer related deaths in men in the Western world. Like many other cancers, ... -
Mechanisms of immune evasion utilised by the Hepatitis C virus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2009)Hepatitis C virus (HCV) is a small, enveloped RNA virus which is distributed worldwide and according to the WHO the number of infected individuals is estimated to be approximately 170 million. HCV creates a heavy burden ... -
Cytokine gene expression, protein expression and genetic variability in the human response to infection
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)In this thesis I explore the hypothesis that a pro-inflammatory cytokine immune response is a beneficial and protective host mechanism in the setting of the human response to infection. The various regulatory pathways ...
