Clinical Medicine (Scholarly Publications): Recent submissions
Now showing items 301-320 of 648
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Patterns of Transcriptional Response to 1,25-Dihydroxyvitamin D3 and Bacterial Lipopolysaccharide in Primary Human Monocytes.
(2016)The active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25D), plays an important immunomodulatory role, regulating transcription of genes in the innate and adaptive immune system. The present study examines patterns of ... -
The Frontal Assessment Battery: Normative Performance in a Large Sample of Older Community-Dwelling Hospital Outpatient or General Practitioner Attenders
(2016)Background: The Frontal Assessment Battery (FAB) is a short battery designed to assess frontal executive functioning, but data for interpretation of performance are limited. Objectives: The Trinity, Ulster, Department ... -
A Common Polymorphism in HIBCH Influences Methylmalonic Acid Concentrations in Blood Independently of Cobalamin
(2016)Methylmalonic acid (MMA) is a by-product of propionic acid metabolism through the vitamin B12 (cobalamin)-dependent enzyme methylmalonyl CoA mutase. Elevated MMA concentrations are a hallmark of several inborn errors of ... -
Determinants of 25-hydroxyvitamin D in older Irish adults.
(2015)Background: vitamin D deficiency is prevalent in older adults living in Northern Europe and is influenced by several factors which may vary significantly with age. Objective: we aimed to investigate the determinants of ... -
Dairy intakes in older Irish adults and effects on vitamin micronutrient status: Data from the TUDA study
(2016)Consumption of dairy products has been associated with positive health outcomes including a lower risk of hypertension, improved bone health and a reduction in the risk of type 2 diabetes. The suggested dairy intake for ... -
A time transect of exomes from a Native American population before and after European contact
(2016)A major factor for the population decline of Native Americans after European contact has been attributed to infectious disease susceptibility. To investigate whether a pre-existing genetic component contributed to this ... -
Single Agent Antihypertensive Therapy and Orthostatic Blood Pressure Behaviour in Older Adults Using Beat-to-Beat Measurements: The Irish Longitudinal Study on Ageing.
(2016)Background Impaired blood pressure (BP) stabilisation after standing, defined using beat-to-beat mea- surements, has been shown to predict important health outcomes. We aimed to define the relationship between individual ... -
Non-invasive molecular tests for H. pylori
(Cogoro, 2016) -
Increased Population Risk of AIP-related Acromegaly and Gigantism in Ireland
(2017)The aryl hydrocarbon receptor interacting protein (AIP) founder mutation R304* (or p.R304*; NM_003977.3:c.910C>T, p.Arg304Ter) identified in Northern Ireland (NI) predisposes to acromegaly/gigantism; its population health ... -
Dysbiosis of salivary microbiota in inflammatory bowel disease and its association with oral immunological biomarkers.
(2014)Analysis of microbiota in various biological and environmental samples under a variety of conditions has recently become more practical due to remarkable advances in next-generation sequencing. Changes leading to specific ... -
Crohn's disease risk alleles on the NOD2 locus have been maintained by natural selection on standing variation.
(2012)Risk alleles for complex diseases are widely spread throughout human populations. However, little is known about the geographic distribution and frequencies of risk alleles, which may contribute to differences in disease ... -
Unequal rates of Y chromosome gene divergence during speciation of the family Ursidae.
(2008)Evolution of the bear family Ursidae is well investigated in terms of morphological, paleontological, and genetic features. However, several phylogenetic ambiguities occur within the subfamily Ursinae (the family Ursidae ... -
Mapping Variation in Cellular and Transcriptional Response to 1,25-Dihydroxyvitamin D3 in Peripheral Blood Mononuclear Cells.
(2016)The active hormonal form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) is an important modulator of the immune system, inhibiting cellular proliferation and regulating transcription of immune response genes. In order to ... -
Ancestral polymorphisms and sex-biased migration shaped the demographic history of brown bears and polar bears.
(2013)Recent studies have reported discordant gene trees in the evolution of brown bears and polar bears. Genealogical histories are different among independent nuclear loci and between biparentally inherited autosomal DNA (aDNA) ... -
Replication of a distinct psoriatic arthritis risk variant at the IL23R locus
(2016)Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with the presence of psoriasis. Although the majority of PsA genetic risk loci identified also confer risk for psoriasis, the difference in ...
