Clinical Medicine (Scholarly Publications): Recent submissions
Now showing items 321-340 of 648
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PTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis: evidence for a further PsA-specific risk locus
(2015)Objectives: Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis; it has a higher estimated genetic component than psoriasis alone, however most genetic susceptibility loci identified for ... -
r2VIM: A new variable selection method for random forests in genome-wide association studies
(2016)Background Machine learning methods and in particular random forests (RFs) are a promising alternative to standard single SNP analyses in genome-wide association studies (GWAS). RFs provide variable importance measures ... -
Patient journey to a specialist amyotrophic lateral sclerosis multidisciplinary clinic: an exploratory study.
(2015)BACKGROUND: The multidisciplinary approach in the management of Amyotrophic Lateral Sclerosis (ALS) has been shown to provide superior care to devolved care, with better survival, improved quality of care, and quality ... -
Analysis of pro [-2] PSA: A novel biomarker that significantly improves the detection of prostate cancer
(2015)Aim: In order to effectively select patients for prostate biopsy more accurate biomarkers of disease are needed. The objective of this study was to analyse the clinical utility of a novel biomarker; pro [-2] PSA in order ... -
Explaining fatigue in ANCA-associated vasculitis
(2013)Objectives. To identify the determinants of fatigue among patients with ANCA-associated vasculitis (AAV). Methods. A multicentre cross-sectional study was conducted. Subjects fulfilling the European Medicines Agency ... -
Markers for work disability in anti-neutrophil cytoplasmic antibody-associated vasculitis.
(2014)Objectives. ANCA-associated vasculitis (AAV) commonly affects those of working age. Since survival rates have been transformed by immunotherapeutics, the measurement of other outcomes has become increasingly relevant. Work ... -
Induction treatment of ANCA-associated vasculitis with a single dose of rituximab.
(2014)Abstract OBJECTIVES: Rituximab is effective in inducing remission in ANCA-associated vasculitis (AAV), with randomized evidence to support its use as four infusions of 375 mg/m(2) (the conventional lymphoma dosing ... -
The Influence of Central Neuropathic Pain in Paraplegic Patients on Performance of a Motor Imagery Based Brain Computer Interface
(2015)Objective The aim of this study was to test how the presence of central neuropathic pain (CNP) influences the performance of a motor imagery based Brain Computer Interface (BCI). Methods In this electroencephalography ... -
Physical Activity and Amyotrophic Lateral Sclerosis: A European Population-Based Case Control Study
(2014)OBJECTIVE: To assess whether physical activity is a risk factor for amyotrophic lateral sclerosis (ALS). METHODS: From February 2008 to April 2012, 652 patients with ALS from European population-based registries ... -
The prevalence of respiratory symptoms among mushroom workers in Ireland
(2014)BACKGROUND: Respiratory conditions such as asthma, bronchitis, hypersensitivity pneumonitis and upper airways symptoms have been ascribed to fungal exposures. Mushroom workers may be at risk of these as a consequence. ... -
A Prospective Study of the Clinical Content of Palliative Medicine Interdisciplinary Team Meetings
(2014)Structured interprofessional communication should improve the structure and clarity of the plan of care. The interdisciplinary team meeting (IDTM) is an opportunity for shared information on patients' and family care needs. ... -
Evidence of Significant Central Fatigue in Patients with Cancer-Related Fatigue during Repetitive Elbow Flexions till Perceived Exhaustion
(2014)OBJECTIVE: To investigate whether fatigue induced by an intermittent motor task in patients with cancer-related fatigue (CRF) is more central or peripheral. METHODS: Ten patients with CRF who were off chemo and ... -
Cancer-related insomnia
(2014)Insomnia increases cancer symptom burden and impairs quality of life. The lack of standard definitions and treatment guidelines makes management difficult. Insomnia is common in most cancers but appears particularly so in ...
