Clinical Medicine (Scholarly Publications): Recent submissions
Now showing items 541-560 of 648
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Adenylate cyclase toxin of Bordetella pertussis inhibits TLR-induced IRF-1 and IRF-8 activation and IL-12 production and enhances IL-10 through MAPK activation in dendritic cells.
(2008)Adenylate cyclase toxin (CyaA) of Bordetella pertussis binds to CD11b/CD18 on macrophages and dendritic cells (DC) and confers virulence to the bacteria by subverting innate immune responses of the host. We have previously ... -
Bcr-Abl regulates osteopontin transcription via Ras, PI-3K, aPKC, Raf-1 and MEK
(2005)Chronic myeloid leukemia (CML) is caused by the constitutively active Bcr-Abl tyrosine kinase. This fusion protein is generated by the Philadelphia translocation t(9;22). CML is a progressive condition that invariably ... -
Molecular Medicine Ireland Guidelines for Standardized Biobanking
(Mary Ann Liebert, Inc, 2010) -
Conditional analysis identifies three novel major histocompatibility complex loci associated with psoriasis
(2012)Psoriasis is a common, chronic, inflammatory skin disorder. A number of genetic loci have been shown to confer risk for psoriasis. Collectively, these offer an integrated model for the inherited basis for susceptibility to ... -
Myeloid KLF2 Regulates the Host Response to Polymicrobial Infection and Endotoxic Shock
(2011)Precise control of myeloid cell activation is required for optimal host defense. However, this activation process must be under exquisite control to prevent uncontrolled inflammation. Herein, we identify the Kruppel-like ... -
Interferon Gamma Release Assays for the Diagnosis of Latent TB Infection in HIV-Infected Individuals in a Low TB Burden Country.
(2013)Background Interferon gamma release assays (IGRAs) are used to diagnose latent tuberculosis infection. Two IGRAs are commercially available: the Quantiferon TB Gold In Tube (QFT-IT) and the T-SPOT.TB. There is debate ... -
Dietary fat, abdominal obesity and smoking modulate the relationship between plasma complement component 3 concentrations and metabolic syndrome risk
(2012)Objective: Chronic inflammation plays a role in the pathogenesis of metabolic syndrome (MetS) and cardiovascular disease (CVD). Complement component 3 (C3) is a novel cardiometabolic risk factor. Whether dietary fat intake ... -
Enhancement of chemokine function as an immunomodulatory strategy employed by human herpesviruses.
(Public Library of Science, 2012-02-02)Herpes simplex virus (HSV) types 1 and 2 are highly prevalent human neurotropic pathogens that cause a variety of diseases, including lethal encephalitis. The relationship between HSV and the host immune system is one of ... -
Syphilis consequences and implications in delayed diagnosis: five cases of secondary syphilis presenting with ocular symptoms.
(2010)Ocular manifestations of syphilis are uncommon. Five cases of ocular syphilis are presented, in four of which there was a delay in diagnosis. Four of the patients were men who have sex with men (MSM), and four patients ... -
The chylomicron: relationship to atherosclerosis.
(2012)The B-containing lipoproteins are the transporters of cholesterol, and the evidence suggests that the apo B48-containing postprandial chylomicron particles and the triglyceride-rich very low density lipoprotein (VLDL) ... -
New fluorescent bile acids: Synthesis, chemical characterization, and disastereoselective uptake by Caco-2 cells of 3-deoxy 3-NBD-amino deoxycholic and ursodeoxycholic acid
(2012)Deoxycholic acid (DCA), a secondary bile acid (BA), and ursodeoxycholic acid (UDCA), a tertiary BA, cause opposing effects in vivo and in cell suspensions. Fluorescent analogues of DCA and UDCA could help investigate ... -
Identification of the synthetic cannabinoid R(+)WIN55,212-2 as a novel regulator of IFN regulatory factor 3 (IRF3) activation and IFN-{beta} expression: relevance to therapeutic effects in models of multiple sclerosis.
(2011)?-Interferons (IFN-?s) represent one of the first line treatments for relapsing-remitting multiple sclerosis, slowing disease progression while reducing the frequency of relapses. Despite this, more effective, well tolerated ... -
Development of Allele-Specific Therapeutic siRNA in Meesmann Epithelial Corneal Dystrophy.
(2011)BACKGROUND: Meesmann epithelial corneal dystrophy (MECD) is an inherited eye disorder caused by dominant-negative mutations in either keratins K3 or K12, leading to mechanical fragility of the anterior corneal epithelium, ... -
A TNF-Regulated Recombinatorial Macrophage Immune Receptor Implicated in Granuloma Formation in Tuberculosis
(PLoS, 2011)Macrophages play a central role in host defense against mycobacterial infection and anti- TNF therapy is associated with granuloma disorganization and reactivation of tuberculosis in humans. Here, we provide evidence for ... -
Post-operative infection and sepsis in humans is associated with deficient gene expression of Yc cytokines and their apoptosis mediators.
(2011)INTRODUCTION: Lymphocyte homeostasis is dependent on the ?c cytokines. We hypothesised that sepsis in humans is associated with differential gene expression of the ?c cytokines and their associated apoptosis mediators. ... -
Biomarkers of folate status in NHANES: a roundtable summary 1-6
(2011)A roundtable to discuss the measurement of folate status biomarkers in NHANES took place in July 2010. NHANES has measured serum folate since 1974 and red blood cell (RBC) folate since 1978 with the use of several different ... -
Platelet Adhesion and Degranulation Induce Pro-Survival and Pro-Angiogenic Signalling in Ovarian Cancer Cells
(2011)Thrombosis is common in ovarian cancer. However, the interaction of platelets with ovarian cancer cells has not been critically examined. To address this, we investigated platelet interactions in a range of ovarian cancer ... -
Phenotype and Function of CD25-Expressing B Lymphocytes Isolated from Human Umbilical Cord Blood
(2011)Background. We have shown that approximately 30% of human peripheral blood B-cells express CD25. B cells expressing CD25 display a mature phenotype belonging to the memory B-cell population and have a better proliferative ... -
Treatment of Helicobacter pylori Infection 2011
(2011)This article reviews the literature published pertaining to Helicobacter pylori eradication over the last year. The general perception among clinicians and academics engaged in research on H. pylori has been that eradication ...
