Clinical Medicine (Scholarly Publications): Recent submissions
Now showing items 561-580 of 648
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Endothelin inhibitors for advanced prostate cancer
(John Wiley, 2011)This is the protocol for a review and there is no abstract. The objectives are as follows: Our review aims to determine the effectiveness and adverse effects of endothelin inhibitors for advanced prostate cancer. The ... -
Bioinformatic and Genetic Association Analysis of MicroRNA Target Sites in One-Carbon Metabolism Genes.
(2011)One-carbon metabolism (OCM) is linked to DNA synthesis and methylation, amino acid metabolism and cell proliferation. OCM dysfunction has been associated with increased risk for various diseases, including cancer and neural ... -
Palliative care in amyotrophic lateral sclerosis: a review of current international guidelines and initiatives
(BMJ, 2011)Background: Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive neurodegenerative condition. Optimal management requires a palliative approach from diagnosis with emphasis on patient autonomy, dignity and ... -
Microneedle Array Design Determines the Induction of Protective Memory CD8+ T Cell Responses Induced by a Recombinant Live Malaria Vaccine in Mice
(PLoS, 2011)Background: Vaccine delivery into the skin has received renewed interest due to ease of access to the immune system and microvasculature, however the stratum corneum (SC), must be breached for successful vaccination. This ... -
SOCS2 regulates T helper type 2 differentiation and the generation of type 2 allergic responses.
(2011)The incidence of allergy and asthma in developed countries is on the increase and this trend looks likely to continue. CD4+ T helper 2 (Th2) cells are major drivers of these diseases and their commitment is controlled by ... -
Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model.
(2010)BACKGROUND: Parasitic helminth infections of humans have been shown to suppress the immune response to allergens. Experimentally, infection of mice with the helminth Schistosoma mansoni prevents allergic airway inflammation ... -
Impaired basophil induction leads to an age-dependent innate defect in type 2 immunity during helminth infection in mice.
(2011)Parasitic-infection studies on rhesus macaque monkeys have shown juvenile animals to be more susceptible to infection than adults, but the immunological mechanism for this is not known. In this study, we investigated the ... -
The hydroxylase inhibitor DMOG attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B-1 cells.
(2011)Localized tissue hypoxia is a feature of infection and inflammation, resulting in the upregulation of the transcription factors HIF-1? and NF-?B via inhibition of oxygen sensing hydroxylase enzymes. Previous studies have ... -
Blockade of B7-H1 (Programmed Death Ligand 1) Enhances Humoral Immunity by Positively Regulating the Generation of T Follicular Helper Cells
(2011)T follicular helper (TFH) cells are critical initiators in the development of T cell-dependent humoral immunity and the generation of protective immunity. We demonstrate that TFH cell accumulation and Ab production are ... -
Symposium on 'The challenge of translating nutrition research into public health nutrition'. Session 3: Joint Nutrition Society and Irish Nutrition and Dietetic Institute Symposium on 'Nutrition and autoimmune disease'. Recent advances in genetic understanding of coeliac disease.
(2009)Over the past 20 years major advances have been made in the diagnosis and understanding of pathogenic mechanisms relating to coeliac disease. Recently-identified genetic markers support the immunological?inflammatory nature ... -
Joint Nutrition Society and Irish Nutrition and Dietetic Institute Symposium on Nutrition and autoimmune disease' Nutrition in Crohn's disease
(2009)The exact aetiology of Crohn's disease remains unknown. The consensus is that the disease results from a complex interaction between genes, immunity and environmental factors. Diet is attractive, in theory, as an environmental ... -
Filaggrin in the frontline: role in skin barrier function and disease.
(Company of Biologists, 2009)Recently, loss-of-function mutations in FLG, the human gene encoding profilaggrin and filaggrin, have been identified as the cause of the common skin condition ichthyosis vulgaris (which is characterised by dry, scaly ... -
Disorders of keratinisation: from rare to common genetic diseases of skin and other epithelial tissues.
(PubMed, 2007)Epithelia are the first line of defence between the human body and its environment. For example, the skin, the largest organ in the body, is covered by the epidermis ? a multilayered, stratified, cornified epithelium that ... -
Receptor tyrosine kinases and their activation in melanoma.
(2011)Receptor tyrosine kinases (RTKs) and their downstream signalling pathways have long been hypothesized to play key roles in melanoma development. A decade ago, evidence was derived largely from animal models, RTK expression ... -
Biomarkers of vitamin B-12 status in NHANES: a roundtable summary 1 6
(2011)A roundtable to discuss the measurement of vitamin B-12 (cobalamin) status biomarkers in NHANES took place in July 2010. NHANES stopped measuring vitamin B-12?related biomarkers after 2006. The roundtable reviewed 3 ... -
Overweight and obesity among older adults upon admission to hospital
(2011)Poor nutritional status, which includes both under- and over-nutrition, is associated with poor health outcomes. This cross-sectional study assessed the nutritional status of older patients admitted to an acute geriatric ... -
The role of epigenetics in resistance to cisplatin chemotherapy in lung cancer
(2011)Non-small cell lung cancer (NSCLC) is the most common cause of cancer related death in the world. Cisplatin and carboplatin are the most commonly used cytotoxic chemotherapeutic agents to treat the disease. These agents, ... -
The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.
(Nature, 2011)Deubiquitinating enzymes are now emerging as potential therapeutic targets that control many cellular processes, but few have been demonstrated to control cell motility. Here, we show that ubiquitin-specific protease 17 ... -
Epigenetic Regulation of Glucose Transporters in Non-Small Cell Lung Cancer
(MDPI, 2011)Due to their inherently hypoxic environment, cancer cells often resort to glycolysis, or the anaerobic breakdown of glucose to form ATP to provide for their energy needs, known as the Warburg effect. At the same time, ... -
The Role of Epigenetics in Resistance to Cisplatin Chemotherapy in Lung Cancer
(2011)Non-small cell lung cancer (NSCLC) is the most common cause of cancer related death in the world. Cisplatin and carboplatin are the most commonly used cytotoxic chemotherapeutic agents to treat the disease. These agents, ...
