School of Genetics & Microbiology: Recent submissions
Now showing items 341-360 of 911
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An examination of Serotonergic candidate genes in Attention Deficit Hyperactivity Disorder
(Trinity College (Dublin, Ireland). Department of Genetics, 2008)Attention Deficit Hyperactivity Disorder (ADHD) is a common, highly heritable childhood disorder. It is characterised by symptoms of inattention, hyperactivity, and impulsivity. Heritability of ADHD is estimated to be ... -
Going fast and getting lost : gene duplication in yeast
(Trinity College (Dublin, Ireland). Department of Genetics, 2007)In this thesis I study how duplicate gene pairs created by a whole-genome duplication in an ancestor of several yeast species were resolved. I show that gene duplication may lead not just to the emergence of new gene ... -
The Dps protein of Salmonella enterica serovar Typhimurium
(Trinity College (Dublin, Ireland). Department of Microbiology, 2008)As a nucleoid-associated protein, Dps has long been thought to influence gene expression at a global level. In this study the role of Dps in genetic regulation in Salmonella enterica serovar Typhimurium was investigated. ... -
The double-edged complexity of molecular sequence evolution
(Trinity College (Dublin, Ireland). Department of Genetics, 2008)Traditionally, phylogenetic studies based on sequence data assume simple models of evolution. This is due to computational and time constraints and to our incomplete understanding of the actual complexity of the evolutionary ... -
On the genetics of retinal function and disease
(Trinity College (Dublin, Ireland). Department of Genetics, 2006)There are many recorded examples in which genetic background has been shown to radically influence retinal phenotypes in inbred mouse strains. For example, the manifestations of a targeted knockout of the p53 gene are much ... -
Effect of intranasal administration of Semliki Forest virus recombinant particles expressing interferon-beta on the progression of experimental autoimmune encephalomyelitis
(Trinity College (Dublin, Ireland). Department of Microbiology, 2006)Multiple sclerosis (MS) is an autoimmune demyelinating disease of the CNS, characterized by the presence of sclerotic lesions throughout the brain. MS is thought to be a CD4+ T helper 1 disease caused by the infiltration ... -
Development of SFV-based plasmid electroporation for use in tumour treatment and vaccine delivery
(Trinity College (Dublin, Ireland). Department of Microbiology, 2008)Electroporation is the delivery of short and intense electric pulses into living cells (either in tissue or suspension), which results in a transient and reversible increase in permeability of the cell transmembrane. This ... -
Molecular analysis of the interaction between protein A of Staphylococcus aureus and von Willebrand factor
(Trinity College (Dublin, Ireland). Department of Microbiology, 2007)Staphylococcus aureus continues to be a major cause of infection in normal as well as immunocompromised hosts, and the increasing prevalence of highly virulent community acquired methicillin-resistant strains is a public ... -
The cell biology of microtubule inhibition in Plasmodium falciparum
(Trinity College (Dublin, Ireland). Department of Microbiology, 2008)Malaria is among the most prevalent human infections worldwide and both the lack of a viable vaccine and the spread of resistance to commonly used drugs have limited the options for control of the parasite, especially ... -
Genetic variation in the bovine genome : signatures of selection and demographic history
(Trinity College (Dublin, Ireland). Department of Genetics, 2008)Domestication, and its associated environmental and demographic changes, undoubtedly brought new challenges to early domesticates, such as cattle. One of the most important would have been the emergence of new disease ... -
Y chromosomes and Irish phylogeography
(Trinity College (Dublin, Ireland). Department of Genetics, 2005)A High-Resolution Y Chromosome Survey of Ireland. In order to investigate the origins of the Irish population and to describe the population genetic events that have shaped the extant Irish gene pool, Y chromosome genetic ... -
The genome of Plasmodium falciparum
(Trinity College (Dublin, Ireland). Department of Microbiology, 2007)The base distribution of the 14 nuclear chromsomes, of the plastid and the mitochondrion of the malarial parasite Plasmodium falciparum were studied. Isochores were discovered in the nuclear chromosomes and found to be ... -
Molecular analysis of surface proteins of staphylococci
(Trinity College (Dublin, Ireland). Department of Microbiology, 2004)S. lugdunensis is an important human pathogen that causes 44% of coagulase negative staphylococcal native valve endocarditis as well as infections such as osteomyelitis and soft tissue abscesses. S. lugdunensis expresses ... -
Analysis of the effects of Beta-Amyloid and age on cell signalling in rat hippocampus : effect of treatment with polyunsaturated fatty acids
(Trinity College (Dublin, Ireland). Department of Microbiology, 2005)Long-term potentiation (LTP) is considered to be a possible neurophysiological model for learning and memory and consistent with this, is the observation that LTP is sensitive to stress, injury and insult. This thesis ... -
Exploration of a therapeutic strategy for osteogenesis imperfecta
(Trinity College (Dublin, Ireland). Department of Genetics, 2007)The studies described in this thesis focus upon an RNAi-base therapeutic approach for the treatment of Col1A1 linked Osteogenesis Imperfecta (OI). OI is an autosomal dominant negative disorder in w hich the presence of ... -
Gene regulation and the leucine-responsive regulatory protein of Salmonella enterica serovar Typhimurium
(Trinity College (Dublin, Ireland). Department of Microbiology, 2007)The leucine-responsive regulatory protein of Escherichia coli (E. coli) is a well characterised global regulator of transcription. Comparatively little is known about the Lrp regulon of Salmonella enterica serovar ... -
Structure-function analysis of the Fim-B and Fim-E site-specific recombinases of Escherichia coli K-12
(Trinity College (Dublin, Ireland). Department of Microbiology, 2006)Phase variable expression of type 1 fimbriae in Escherichia coli arises from a site-specific recombination event that inverts a 314 bp segment of chromosomal DNA (fimS) carrying the promoter for transcription of the gene ... -
Mitochondrial genes associated with cytoplasmic male sterility in Lolium perenne
(Trinity College (Dublin, Ireland). Department of Genetics, 2008)This study involved molecular investigations of cytoplasmic male sterility (CMS) in perennial ryegrass (Lolium perenne L). The CMS line originated as an interspecific hybrid between L. perenne (male parent) and Festuca ... -
Protein A Is Released into the Staphylococcus aureus Culture Supernatant with an Unprocessed Sorting Signal.
(2015)The immunoglobulin binding protein A (SpA) of Staphylococcus aureus is synthesized as a precursor with a C-terminal sorting signal. The sortase A enzyme mediates covalent attachment to peptidoglycan so that SpA is displayed ... -
Cell signalling and ADP ribosylation factor 1 (Arf1) effector proteins of African trypanosomes
(Trinity College (Dublin, Ireland). Department of Genetics, 2008)The control of population size and differentiation status is essential for the survival of all organisms. Tight regulation of these processes is of particular importance for parasites. The African trypanosome, Trypanosoma ...
