School of Genetics & Microbiology: Recent submissions

Now showing items 361-380 of 911

    • Characterisation of the Rns transcriptional regulator of enterotoxigenic Escherichia coli and regulationf of CS1 fimbrial expression 

      Mahon, Vivienne (Trinity College (Dublin, Ireland). Department of Microbiology, 2008)
      Enterotoxigenic Escherichia coli (ETEC) is a major cause of diarrhoea amongst children in developing countries and travellers to such countries. Virulence in ETEC is dependent on both toxin production and adherence of the ...

    • Examinations of DRD4, DRD5 and SNAP-25 as candidate genes in Attention Deficit Hyperactivity Disorder 

      Lowe, Naomi Temple (Trinity College (Dublin, Ireland). Department of Genetics, 2005)
      Attention deficit hyperactivity disorder (ADHD) is a common early onset childhood disorder. Symptoms o f the disorder include inattentiveness, impulsiveness, distractibility and hyperactivity. Family, twin and adoption ...

    • Platelet activation by Staphylococcus aureus 

      Loughman, Anthony J. (Trinity College (Dublin, Ireland). Department of Microbiology, 2006)
      Staphylococcus aureus is the leading cause of infective endocarditis (IE). Platelet activation promoted by S. aureus resulting in aggregation and thrombus formation is thought to be an important step in the pathogenesis ...

    • Sequence analysis of alphavirus pathogenesis 

      Logue, Christopher H. (Trinity College (Dublin, Ireland). Department of Microbiology, 2006)
      This investigation involved the sequencing and characterisation of Chikungunya virus (CHIKV), a positive-stranded RNA virus with a genome spanning 11.8 kb. The prototype strain of CHIKV, termed Ross was used. This is the ...

    • Molecular characterisation of Region A of FnBPA from Staphylococcus aureus 

      Keane, Fiona Mary (Trinity College (Dublin, Ireland). Department of Microbiology, 2007)
      The surface-expressed fibronectin-binding proteins, FnBPA and FnBPB, of Staphylococcus aureus promote attachment to immobilised fibrinogen and elastin via the N-Terminal A region. The N2N3 subdomains of region A were found ...

    • Studies on clumping Factor A of Staphylococcus aureus 

      Higgins, Judy (Trinity College (Dublin, Ireland). Department of Microbiology, 2006)
      Clumping factor A is a fibrinogen-binding protein of S. aureus. It is a cell wall associated protein consisting of an N-terminal ligand-binding region A, an unusual SD dipeptide repeat region, which acts as a stalk to ...

    • Characterization of two flowering gene homologues from Lolium perenne 

      Hayes, James (Trinity College (Dublin, Ireland). Department of Genetics, 2005)
      Lolium perenne (perennial ryegrass) is a primary source of fodder for grazing cattle and is therefore of significant agricultural and economic importance. Understanding the flowering process in this species may help to ...

    • Genomic evolution of polyploid yeast species 

      Gordon, Jonathan (Trinity College (Dublin, Ireland). Department of Genetics, 2008)
      In Chapter 2 of this thesis I study how the genome structure and content of yeast has evolved since a Whole Genome Duplication (WGD) occurred in the lineage approximately 100 million years ago. By using genome data from ...

    • Tumour therapy using cytokine-expressing semliki forest virus vectors 

      Gowda C. P. Chikkanna (Trinity College (Dublin, Ireland). Department of Microbiology, 2005)
      Semliki Forest Virus (SFV) vector is a transient RNA based suicidal expression vector system and has been previously used as a potential anti-cancer agent. Recently, a new enhanced SFV vector has been developed, pSFV10-E. ...

    • Molecular characterisation of the Salmonella-specific protein PagN 

      Lambert, Matthew A. (Trinity College (Dublin, Ireland). Department of Microbiology, 2007)
      Salmonella infect a broad spectrum of animals resulting in host responses ranging from severe disease to asymptomatic carriage. Infection of a host gives rise to symptoms such as fever or self-limiting gastroenteritis. ...

    • Evolutionary genomics of filamentous fungi 

      Khaldi, Nora (Trinity College (Dublin, Ireland). Department of Genetics, 2008)
      Filamentous fungi are important producers of secondary metabolites (SMs), together with plants and bacteria. While some SMs are toxic to humans, animals or plants, many others are beneficial. The discovery that the genes ...

    • Immune responses to cereal prolamin proteins in coeliac disease 

      Kilmartin, Claire (Trinity College (Dublin, Ireland). Department of Microbiology, 2004)
      Coeliac disease is an inflammatory disease of the small intestine, precipitated in susceptible individuals by gliadin, the alcohol soluble (prolamin) fraction of wheat gluten. There is a strong genetic influence on ...

    • Therapeutic stratagems for dominant genetic disorders 

      Kernan, Fiona (Trinity College (Dublin, Ireland). Department of Genetics, 2006)
      Autosomal dominant genetic diseases exhibit a phenotype when one gene allele is mutated whereas recessive diseases require both alleles to be mutated for disease pathology to arise. Disease alleles inherited in a dominant ...

    • Studies on Irish families with autosomal dominant retinitis pigmentosa, congenital stationary night blindness and on mouse models of inherited retinopathies 

      Kenna, Paul F. (Trinity College (Dublin, Ireland). Department of Genetics, 2007)
      This thesis describes over 17 years of research into the molecular genetics of inherited retinopathies including Retinitis Pigmentosa (RP), the most prevalent form of inherited blindness world-wide, and Congenital Stationary ...

    • Gene regulation and the Fis nucleoid-associated protein in Salmonella enterica serovar Typhimurium 

      Kelly, Arlene (Trinity College (Dublin, Ireland). Department of Microbiology, 2005)
      The Fis protein was found to influence the superhelical density of DNA and its ability to do this differed between Salmonella enterica serovar Typhimurium (S. typhimurium) and Escherichia coli (E. coli). Induction of the ...

    • Bovini mitochondrial DNA : demographic history and recombination 

      Finlay, Emma (Trinity College (Dublin, Ireland). Department of Genetics, 2006)
      Bovini mitochondrial sequences were analysed at levels from intra-population studies to inter-species analyses. D-loop sequences were analysed to draw conclusions about the domestication of water buffalo and the demographic ...

    • Investigation of microtubule inhibitors as potential antimalarial agents 

      Fennell, Brian (Trinity College (Dublin, Ireland). Department of Microbiology, 2005)
      Malaria is a parasitic infection of immense global importance. The most common and severe form of the disease is caused by the blood-bome apicomplexan parasite Plasmodium falciparum. The lack of an effective vaccine coupled ...

    • Adhesion and invasion by Escherichia coli K1 

      Fagan, Robert (Trinity College (Dublin, Ireland). Department of Microbiology, 2006)
      Escherichia coli is one of the principal causes of septicaemia and meningitis in neonates. Sepsis occurs in approximately one in every thousand live births, with up to 10% progressing to develop meningitis. A disproportionate ...

    • Characterisation of Sfh, a novel H-NS-like protein 

      Doyle, Marie (Trinity College (Dublin, Ireland). Department of Microbiology, 2006)
      Members of the H-NS protein family are widespread among Gram-negative bacteria and are known to influence gene expression at a global level. Shigella flexneri serotype 2a strain 2457T expresses three members of the H-NS ...

    • Role of CED-9/cl-2 family proteins in mitochondrial fission and fusion dynamics 

      Delivani, Petrina (Trinity College (Dublin, Ireland). Department of Genetics, 2008)
      Programmed cell death in the nematode C. elegans is the equivalent process to human apoptosis. Studying this process in the model organism has led to a great amount of knowledge about the details of pathway steps and ...