Psychiatry: Recent submissions
Now showing items 381-400 of 438
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Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.
(Nature Publishing Group, 2009-11-15)Ulcerative colitis is a common form of inflammatory bowel disease with a complex etiology. As part of the Wellcome Trust Case Control Consortium 2, we performed a genome-wide association scan for ulcerative colitis in 2,361 ... -
Clinical symptomatology and the psychosis risk gene, ZNF804A
(2010)The single nucleotide polymorphism (SNP) rs1344706, mapping to the gene ZNF804A, has been implicated in schizophrenia susceptibility ([O'Donovan et al., 2008], [International Schizophrenia Consortium, 2009], [Stefansson ... -
Multicentre variability of MRI-based medial temporal lobe volumetry in Alzheimer's disease
(Elsevier, 2010)Magnetic resonance imaging (MRI)-based volumetry of medial temporal lobe regions is among the best established biomarker candidates of Alzheimer's disease (AD) to date. This study assessed the effect of multicentre variability ... -
Influence of NOS1 on verbal intelligence and working memory in both patients with schizophrenia and healthy control subjects.
(2009)Background: Human and animal studies have implicated the gene NOS1 in both cognition and schizophrenia susceptibility. Objectives: To investigate whether a potential schizophrenia risk SNP (rs6490121) identified in a recent ... -
The Imperative for Disease Modifying Treatments in Alzheimer s Disease
(Medical Association of Ireland, 2009)It is estimated that there are currently as many as 38,000 people with dementia in Ireland and that this figure may exceed 70,000 by 2026.1 Indeed the prevalence of dementia is rising worldwide and it is not surprising ... -
The Dundrum Toolkit. Dangerousness, Understanding, Recovery and Urgency Manual (The Dundrum Quartet). Four Structured Professional Judgement Instruments for Admission Triage, Urgency, Treatment Completion and Recovery Assessments
(Trinity College Dublin, 2010)The DUNDRUM QUARTET: This handbook describes a suite of four structured professional judgement instruments. These structured professional judgement instruments are intended to provide a validated and transparent means ... -
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
(2009)We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD) involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 (3,941 cases and 7,848 controls), we replicated the ... -
Evidence that genetic variation in the oxytocin receptor (OXTR) gene influences social cognition in ADHD
(2010)Some children with ADHD also have social and communication difficulties similar to those seen in children with autistic spectrum disorders and this may be due to shared genetic liability. As the oxytocin receptor (OXTR) ... -
Amyotrophic lateral sclerosis mutant vesicle-associated membrane protein-associated protein-B transgenic mice develop TAR-DNA-binding protein-43 pathology.
(2010)Cytoplasmic ubiquitin-positive inclusions containing TAR-DNA-binding protein-43 (TDP-43) within motor neurons are the hallmark pathology of sporadic amyotrophic lateral sclerosis (ALS). TDP-43 is a nuclear protein and the ... -
Expression of the Neuronal Adaptor Protein X11alpha Protects Against Memory Dysfunction in a Transgenic Mouse Model of Alzheimer's Disease
(2010)X11? is a neuronal-specific adaptor protein that binds to the amyloid-? protein precursor (A?PP). Overexpression of X11? reduces A? production but whether X11? also protects against A?-related memory dysfunction is not ... -
The Wellcome trust UK-Irish bipolar affective disorder sibling-pair genome screen: first stage report
(Nature Publishing Group, 2002)We have completed the first stage of a two-stage genome wide screen designed to identify chromosomal regions that may harbour susceptibility genes for bipolar affective disorder. The first stage screening sample included ... -
Evidence that variation at the serotonin transporter gene influences susceptibility to attention deficit hyperactivity disorder (ADHD): analysis and pooled analysis.
(2002)Reduced central serotonergic activity has been implicated in poor impulse regulation and aggressive behaviour in animals, adults and also young children.1,2 Two recently published studies have implicated variation at a ... -
Serotonergic System and Attention Deficit Hyperactivity Disorder (ADHD): a potential susceptibility locus at the 5-HT1B receptor gene in 270 Trios from a multi-center sample
(2002)Attention deficit hyperactivity disorder (ADHD) is a highly heritable and heterogeneous disorder, which usually becomes apparent during the first few years of childhood. Imbalance in dopamine neurotransmission has been ... -
Dopa decarboxylase gene polymorphisms and attention deficit hyperactivity disorder (ADHD): no evidence for association in the Irish population
(2001)Dopa decarboxylase (DDC) is an enzyme which catalyses the decarboxylation of both dopa to dopamine and L-5 hydroxytryptophan to serotonin. Both catecholamines are major neurotransmitters of the mammalian nervous system. ... -
Cigarette smoking and psychotic symptoms in bipolar affective disorder
(The Royal College of Psychiatrists, 2001)Background An association exists between smoking and schizophrenia, independent of other factors and related to psychotic symptomatology. Aims To determine whether smoking is associated with psychosis in bipolar affective ... -
Lack of gender effect on familial schizophrenia. A Brazilian study.
(Arquivos de Neuro Psiquiatria / Academia Brasileira de Neurologia - ABNEURO, 2000)Estudos epidemiologicos em esquizofrenia estabeleceram que a idade de inicio para o genero masculino precede em alguns anos aquela para o feminino. No entanto, tal efeito de genero n?o vem sendo observado para os casos ... -
Synaptosomal-Associated Protein 25 (SNAP-25) and Attention Deficit Hyperactivity Disorder (ADHD): Evidence of linkage and Association in the Irish Population.
(2002)Several lines of evidence have suggested that ADHD is a polygenic disorder produced by the interaction of several genes each of a minor effect. Synaptosomal-associated protein 25 (SNAP-25) is a presynaptic plasma membrane ... -
Dopaminergic system genes in ADHD: toward a biological hypothesis
(2002)Converging evidence has implicated abnormalities of dopamine neurotransmission to the pathology of attention deficit hyperactivity disorder (ADHD). Several genetic association studies have been published, but so far, no ... -
Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder
(2003)Genome scans of bipolar disorder (BPD) have not produced consistent evidence for linkage. The rank-based genome scan meta-analysis (GSMA) method was applied to 18 BPD genome scan data sets in an effort to identify regions ... -
Joint Analysis of the DRD5 Marker Concludes Association with Attention-Deficit/Hyperactivity Disorder Confined to the Predominantly Inattentive and Combined Subtypes
(2004)Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable, heterogeneous disorder of early onset, consisting of a triad of symptoms: inattention, hyperactivity, and impulsivity. The disorder has a significant ...
