Microbiology: Recent submissions

Now showing items 121-140 of 333

    • Development of SFV-based plasmid electroporation for use in tumour treatment and vaccine delivery 

      Piggott, John M. (Trinity College (Dublin, Ireland). Department of Microbiology, 2008)
      Electroporation is the delivery of short and intense electric pulses into living cells (either in tissue or suspension), which results in a transient and reversible increase in permeability of the cell transmembrane. This ...

    • Molecular analysis of the interaction between protein A of Staphylococcus aureus and von Willebrand factor 

      O Séaghdha, Mághnus N. (Trinity College (Dublin, Ireland). Department of Microbiology, 2007)
      Staphylococcus aureus continues to be a major cause of infection in normal as well as immunocompromised hosts, and the increasing prevalence of highly virulent community acquired methicillin-resistant strains is a public ...

    • The cell biology of microtubule inhibition in Plasmodium falciparum 

      Naughton, Julie Ann (Trinity College (Dublin, Ireland). Department of Microbiology, 2008)
      Malaria is among the most prevalent human infections worldwide and both the lack of a viable vaccine and the spread of resistance to commonly used drugs have limited the options for control of the parasite, especially ...

    • The genome of Plasmodium falciparum 

      Mitchell, David Patrick (Trinity College (Dublin, Ireland). Department of Microbiology, 2007)
      The base distribution of the 14 nuclear chromsomes, of the plastid and the mitochondrion of the malarial parasite Plasmodium falciparum were studied. Isochores were discovered in the nuclear chromosomes and found to be ...

    • Molecular analysis of surface proteins of staphylococci 

      Mitchell, Jennifer (Trinity College (Dublin, Ireland). Department of Microbiology, 2004)
      S. lugdunensis is an important human pathogen that causes 44% of coagulase negative staphylococcal native valve endocarditis as well as infections such as osteomyelitis and soft tissue abscesses. S. lugdunensis expresses ...

    • Analysis of the effects of Beta-Amyloid and age on cell signalling in rat hippocampus : effect of treatment with polyunsaturated fatty acids 

      Minogue, Aedín (Trinity College (Dublin, Ireland). Department of Microbiology, 2005)
      Long-term potentiation (LTP) is considered to be a possible neurophysiological model for learning and memory and consistent with this, is the observation that LTP is sensitive to stress, injury and insult. This thesis ...

    • Gene regulation and the leucine-responsive regulatory protein of Salmonella enterica serovar Typhimurium 

      McFarland, Kirsty A. (Trinity College (Dublin, Ireland). Department of Microbiology, 2007)
      The leucine-responsive regulatory protein of Escherichia coli (E. coli) is a well characterised global regulator of transcription. Comparatively little is known about the Lrp regulon of Salmonella enterica serovar ...

    • Structure-function analysis of the Fim-B and Fim-E site-specific recombinases of Escherichia coli K-12 

      McCusker, Matthew Patrick (Trinity College (Dublin, Ireland). Department of Microbiology, 2006)
      Phase variable expression of type 1 fimbriae in Escherichia coli arises from a site-specific recombination event that inverts a 314 bp segment of chromosomal DNA (fimS) carrying the promoter for transcription of the gene ...

    • Protein A Is Released into the Staphylococcus aureus Culture Supernatant with an Unprocessed Sorting Signal. 

      Geoghegan, Joan; O'Halloran, Dara; Wynne, Kieran (2015)
      The immunoglobulin binding protein A (SpA) of Staphylococcus aureus is synthesized as a precursor with a C-terminal sorting signal. The sortase A enzyme mediates covalent attachment to peptidoglycan so that SpA is displayed ...

    • Characterisation of the Rns transcriptional regulator of enterotoxigenic Escherichia coli and regulationf of CS1 fimbrial expression 

      Mahon, Vivienne (Trinity College (Dublin, Ireland). Department of Microbiology, 2008)
      Enterotoxigenic Escherichia coli (ETEC) is a major cause of diarrhoea amongst children in developing countries and travellers to such countries. Virulence in ETEC is dependent on both toxin production and adherence of the ...

    • Platelet activation by Staphylococcus aureus 

      Loughman, Anthony J. (Trinity College (Dublin, Ireland). Department of Microbiology, 2006)
      Staphylococcus aureus is the leading cause of infective endocarditis (IE). Platelet activation promoted by S. aureus resulting in aggregation and thrombus formation is thought to be an important step in the pathogenesis ...

    • Sequence analysis of alphavirus pathogenesis 

      Logue, Christopher H. (Trinity College (Dublin, Ireland). Department of Microbiology, 2006)
      This investigation involved the sequencing and characterisation of Chikungunya virus (CHIKV), a positive-stranded RNA virus with a genome spanning 11.8 kb. The prototype strain of CHIKV, termed Ross was used. This is the ...

    • Molecular characterisation of Region A of FnBPA from Staphylococcus aureus 

      Keane, Fiona Mary (Trinity College (Dublin, Ireland). Department of Microbiology, 2007)
      The surface-expressed fibronectin-binding proteins, FnBPA and FnBPB, of Staphylococcus aureus promote attachment to immobilised fibrinogen and elastin via the N-Terminal A region. The N2N3 subdomains of region A were found ...

    • Studies on clumping Factor A of Staphylococcus aureus 

      Higgins, Judy (Trinity College (Dublin, Ireland). Department of Microbiology, 2006)
      Clumping factor A is a fibrinogen-binding protein of S. aureus. It is a cell wall associated protein consisting of an N-terminal ligand-binding region A, an unusual SD dipeptide repeat region, which acts as a stalk to ...

    • Tumour therapy using cytokine-expressing semliki forest virus vectors 

      Gowda C. P. Chikkanna (Trinity College (Dublin, Ireland). Department of Microbiology, 2005)
      Semliki Forest Virus (SFV) vector is a transient RNA based suicidal expression vector system and has been previously used as a potential anti-cancer agent. Recently, a new enhanced SFV vector has been developed, pSFV10-E. ...

    • Molecular characterisation of the Salmonella-specific protein PagN 

      Lambert, Matthew A. (Trinity College (Dublin, Ireland). Department of Microbiology, 2007)
      Salmonella infect a broad spectrum of animals resulting in host responses ranging from severe disease to asymptomatic carriage. Infection of a host gives rise to symptoms such as fever or self-limiting gastroenteritis. ...

    • Immune responses to cereal prolamin proteins in coeliac disease 

      Kilmartin, Claire (Trinity College (Dublin, Ireland). Department of Microbiology, 2004)
      Coeliac disease is an inflammatory disease of the small intestine, precipitated in susceptible individuals by gliadin, the alcohol soluble (prolamin) fraction of wheat gluten. There is a strong genetic influence on ...

    • Gene regulation and the Fis nucleoid-associated protein in Salmonella enterica serovar Typhimurium 

      Kelly, Arlene (Trinity College (Dublin, Ireland). Department of Microbiology, 2005)
      The Fis protein was found to influence the superhelical density of DNA and its ability to do this differed between Salmonella enterica serovar Typhimurium (S. typhimurium) and Escherichia coli (E. coli). Induction of the ...

    • Investigation of microtubule inhibitors as potential antimalarial agents 

      Fennell, Brian (Trinity College (Dublin, Ireland). Department of Microbiology, 2005)
      Malaria is a parasitic infection of immense global importance. The most common and severe form of the disease is caused by the blood-bome apicomplexan parasite Plasmodium falciparum. The lack of an effective vaccine coupled ...

    • Adhesion and invasion by Escherichia coli K1 

      Fagan, Robert (Trinity College (Dublin, Ireland). Department of Microbiology, 2006)
      Escherichia coli is one of the principal causes of septicaemia and meningitis in neonates. Sepsis occurs in approximately one in every thousand live births, with up to 10% progressing to develop meningitis. A disproportionate ...