Clinical Medicine: Recent submissions
Now showing items 141-160 of 1003
-
The Plasticity of Neutrophil Subsets in Inflammation
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Neutrophils are a vital component of the innate immune system and the body s first line of defense against invading pathogens. The classic view of these cells is that they are a homogenous population of terminally ... -
An exploration of the role of the clinical academic and strategies to sustain and build the clinical academic workforce
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Background Clinical academics are critical to delivering high quality patient care and discovering new ways to treat disease (1), however the clinical academic workforce is shrinking (2-4). There is a need to clearly ... -
Advanced histology methods for biodistribution and safety screening of next generation nanobiomaterials
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Over the past few decades nanobiomaterials (NBMs) have shown a promise in improving many areas of medicine such as diagnosis and treatment of diseases, with number of formulations currently approved for use by the regulators. ... -
Nomenclature and Definition of Atrophic Lesions in Small Bowel Capsule Endoscopy: An International Delphi Consensus Statement of the International CApsule Endoscopy REsearch (I-CARE) Group.
(2022)Background: Villous atrophy is an indication for small bowel capsule endoscopy (SBCE). However, SBCE findings are not described uniformly and atrophic features are sometimes not recognized; (2) Methods: The Delphi technique ... -
What does the ALSFRS-R really measure? A longitudinal and survival analysis of functional dimension subscores in amyotrophic lateral sclerosis
(2017)Introduction: ALSFRS-R is the most widely used functional rating system in ALS patients. However, heterogeneity in ALSFRS-R progression renders analysis challenging. We have explored the characteristics of total ALSFRS-R, ... -
Food Allergy among Irish Children: An Exploration of the Risk and Impact of Accidental Allergic Reactions
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Introduction Food allergy (FA) now impacts almost 1 in 20 Irish children. These children are at risk of allergic reactions and anaphylaxis. Food is an integral part of all social activities, and thus children with FA ... -
Thrombin generation parameters, relationship with cerebral micro-embolic signal status, and a systematic review of the literature on platelet biomarkers in patients with symptomatic and asymptomatic carotid stenosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Background:?Activation of platelets and the coagulation system are integrally involved in acute thrombus formation and distal thrombo-embolism. A better understanding of these complex thrombotic and haemostatic pathways ... -
Adaptive and Innate TH1 and TH17 Responses in Elderly Hospitalised Patients with Infection and Sepsis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Introduction: Sepsis carries a significant burden to health care. Almost a third of ICU patients have sepsis on admission or develop it during their admission. Sepsis carries a high mortality and affects all age groups ... -
Heart Rate Recovery Velocity in Cardiac Disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Introduction Rate of recovery of heart rate between 10 and 20 seconds following orthostatic challenge (HRR10-20) is a risk factor for all-cause mortality. Furthermore, both cardiac rehabilitation and completeness of coronary ... -
Hungry for More: Measuring Metabolomic Responses in ANCA-Activated Monocytes
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Immunometabolism examines the links between immune cell function and their metabolism. Advances in liquid chromatography mass spectrometry (LC-MS) technologies have uncovered unique insights into cellular metabolomics. ... -
Neuropsychological and Neuropsychiatric Endophenotypes in Amyotrophic Lateral Sclerosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease, characterized by progressive muscle weakness and death, usually within 3-5 years from symptom onset. ALS is now recognized to be a multi-system ... -
Cytosolic dsRNA improves neonatal innate immune responses to adjuvants in use in paediatric vaccines.
(2022)Pattern recognition receptors (PRRs) of the innate immune system represent the critical front-line defense against pathogens, and new vaccine formulations target these PRR pathways to boost vaccine responses, through ... -
Minocycline suppresses disease-associated microglia (DAM) in a model of photoreceptor cell degeneration
(2022)As the resident immune cells in the retina, microglia play important homeostatic roles in retinal immune regulation and neuroprotection. However, chronic microglia activation is a common hallmark of many degenerative retinal ... -
SARM1 Promotes Photoreceptor Degeneration in an Oxidative Stress Model of Retinal Degeneration
(2022)SARM1 (sterile alpha and armadillo motif-containing protein) is a highly conserved Toll/IL-1 Receptor (TIR) adaptor with important roles in mediating immune responses. Studies in the brain have shown that SARM1 plays a ... -
Network Analysis in Motor Neuron Diseases: A Cortico-Muscular Coherence Study
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Neurodegenerative conditions are associated with widespread changes in the motor networks. There is preliminary evidence from (f)MRI studies that the structural changes extend beyond the primary motor areas in cortical ... -
Detection of Neurovascular Compression in Trigeminal Neuralgia by high-resolution Magnetic Resonance Angiography
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Trigeminal neuralgia (TGN, tic douloureux) refers to sudden severe paroxysms of severe lancinating pain on one side of the face involving one or more branches of the trigeminal nerve (CN V) which usually lasts a few seconds ... -
IL-36 cytokines imprint a colitogenic phenotype on CD4+ T helper cells.
(2022)IL-36 cytokines are emerging as potent orchestrators of intestinal inflammation and are being implicated in the pathogenesis of inflammatory bowel diseases (IBD). However, the mechanisms through which these cytokines mediate ... -
Immunometabolic responses of adult and umbilical cord macrophages to stimulation with Mycobacterium tuberculosis or Lipopolysaccharide
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Tuberculosis (TB) has been the biggest infectious killer in the world in the last decade and young children are among the most vulnerable groups. Mycobacterium tuberculosis (Mtb), the bacteria that causes TB, is phagocytosed ... -
Cerebral Blood Flow and Cerebrovascular Reactivity Measurement using Arterial Spin Labeling MRI: Data from The Irish Longitudinal Study on Ageing (TILDA)
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Background: Cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) are important measures of cerebrovascular integrity and may provide an imaging biomarker for the early detection of diseases such as dementia and ... -
Does the future of epilepsy care lie in eHealth? An examination of attitudes and behaviours towards epilepsy self-management and eHealth from the perspectives of people with epilepsy, their carers and healthcare providers
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)
