Clinical Medicine: Recent submissions
Now showing items 161-180 of 1003
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Total correlation explanation of toxic metal concentrations and physiological biomarkers amongst NHANES participants
(2021)Introduction Unravelling the health effects of multiple pollutants presents scientific and computational challenges. CorEx is an unsupervised learning algorithm that can efficiently discover multiple latent factors in ... -
Cognitive reserve in amyotrophic lateral sclerosis (ALS): a population-based longitudinal study.
(2021)Background Amyotrophic lateral sclerosis (ALS) is often associated with cognitive and/or behavioural impairment. Cognitive reserve (CR) may play a protective role in offsetting cognitive impairment. This study examined the ... -
HIP FRACTURES IN OLDER ADULTS AND TREATMENT WITH INTRAVENOUS ZOLEDRONIC ACID
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Introduction: Osteoporotic hip fractures are common in older adults and are responsible for significant morbidity and mortality. Structured geriatric care for older adults with hip fracture is known to improve outcomes. A ... -
The Complexities of Antimicrobial Resistance in Acute Care: An Exploration of Key Actors and Factors Associated with Acute Care Antimicrobial Stewardship
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Background Antimicrobial resistance (AMR) is an evolving global healthcare emergency, of which a significant driver is the use and overuse of antimicrobials. Antimicrobial stewardship (AMS) is a multi-component, multidisciplinary ... -
On dignity in inpatient psychiatric care
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Dignity is an important concept in human rights legislation and medical ethics but is under-studied in psychiatric settings. It is a nuanced concept which is considered difficult to define, but nevertheless has a prominent ... -
Variation in clinical outcomes and immune consequences following two viral infections
Ageing is associated with increasing rates of ill-health. However, the burden of ill-health is not evenly distributed across ageing populations. The term biological age captures the consequences of ageing more effectively ... -
Recurrence of venous thromboembolism in patients with gynaecological cancer incidence, risk factors and impact on survival
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Background: Gynaecological malignancy and surgery are independently associated with the highest risks of VTE. However, factors influencing the rate of recurrent VTE in patients with gynaecological malignancy are unknown. ... -
Implications of Cardiovascular Ageing for Cerebral Perfusion and Cognitive Performance
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)The aim of this thesis is to examine how common manifestations of cardiovascular ageing, Orthostatic Hypotension and Atrial Fibrillation, affect cerebral perfusion and cognitive function in Irish adults. Associations between ... -
Genetic Epidemiology and Cognitive Endophenotyping in Amyotrophic Lateral Sclerosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Amyotrophic Lateral Sclerosis (ALS) is a progressive debilitating and ultimately fatal neurodegenerative disorder affecting both upper (UMN) and lower (LMN) motor neurons. While it has been long known to exist on a spectrum ... -
The Effect of Tuberculosis Antimicrobials on the Immunometabolic Profiles of Primary Human Macrophages Stimulated with Mycobacterium tuberculosis
(2021)Tuberculosis (TB) remains a global health challenge. Patients with drug-sensitive and drug-resistant TB undergo long, arduous, and complex treatment regimens, often involving multiple antimicrobials. While these drugs were ... -
The Generation and Characterisation of Novel Mouse Models of Haemophilia A
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Haemophilia A (HA) is a hereditary, X-linked recessive disease caused by mutations in the F8 gene, with the absence or deficiency in the coagulation factor, Factor VIII (FVIII), resulting in a bleeding diathesis. The ... -
NEURODEVELOPMENTAL OUTCOME FOR TWINS OF THE ESPRiT STUDY: THE NOTES STUDY
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)THE NOTES STUDY: ABSTRACT Objective: The objective of the NOTES Study was to study the effect of birthweight growth discordance (≥ 20%) on neurodevelopmental outcome and physical growth of monochorionic and dichorionic ... -
The clinical and neuroimaging profiles of primary lateral sclerosis: a longitudinal research study
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Primary Lateral Sclerosis (PLS) is a progressive, idiopathic upper motor neuron (UMN) disease. Clinically, PLS is defined by the presence of spasticity and associated UMN signs without concurrent evidence of lower motor ... -
In-depth profiling of drug resistance to PI3K-mTOR inhibition and intra-tumour heterogeneity in NSCLC
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Lung cancer has an overall 5-year survival rate of less than 15% and is the leading cause of cancer-related death worldwide. As such, it is crucial we develop new treatment strategies to overcome this formidable disease. ... -
Investigating the role of IL-36 cytokines in mediating angiogenesis and vascular permeability
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Neovascular blinding conditions including age related macular degeneration and diabetic retinopathy are the most common causes of blindness in the elderly and working age populations respectively. Currently the best-in-class ... -
Defining the role of RORα in the functionality of distinct immune cell populations
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)The transcription factor Retinoic acid-related Orphan Receptor (ROR)-a has roles in metabolism, circadian rhythm and cellular development, such as Th17 cells and group 2 innate lymphoid cells (ILC2). The identification ... -
Ketamine for depression: Clinical use and media accounts
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)This thesis comprises two research studies, one of which is a clinical trial. Study 1: Pilot randomised controlled trial: Ketamine as an adjunctive therapy for major depression, the Karma-Dep Trial (NCT03256162). The ... -
Study of Macular Pigments in Glaucoma
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)The macula can be involved in the early stage of glaucoma, as evidenced by the presence of paracentral scotoma on visual field tests (Drance 1969) or thinning of the ganglion cell complex (GCC) layer on optical coherence ... -
The Iron Chelator Desferrioxamine Increases the Efficacy of Bedaquiline in Primary Human Macrophages Infected with BCG
(2021)For over 50 years, patients with drug-sensitive and drug-resistant tuberculosis have undergone long, arduous, and complex treatment processes with several antimicrobials. With the prevalence of drug-resistant strains on ... -
Assessing the Efficacy and Safety of Bimodal Neuromodulation for the Management of Symptomatic Tinnitus
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Tinnitus is defined as the perception of sound in the absence of an external auditory stimulus. It is a common symptom, affecting 5 30% of the general population, however only 1 3% of patients report the symptom to be ...
