Clinical Medicine: Recent submissions
Now showing items 281-300 of 1003
-
Prevalence of frailty among community dwelling older adults in receipt of low level home support: a cross-sectional analysis of the North Dublin Cohort
(2017)Background: There is increasing demand for formal government funded home help services to support community-dwelling older people in Ireland, yet limited information exists on the health profiles of this group, especially ... -
Home enteral nutrition recipients: patient perspectives on training, complications and satisfaction
(2017)The equitable provision of home enteral nutrition (HEN) in the community can have a transformative effect on patient experience and family life for adults and children alike. While optimising quality of life in HEN patients ... -
High prevalence of dementia among community dwelling older adults in receipt of state funded home care packages: implications for health care planning
(2017)Objectives: The majority of people living with dementia in Ireland reside in their own homes, some supported by formal or informal home care. This audit aimed to estimate the prevalence of dementia and suspected cognitive ... -
Examining the utility of cystatin C as a confirmatory test of chronic kidney disease across the age range in middle-aged and older community-dwelling adults
(2018)Background: Cystatin C has been proposed as a confirmatory test of chronic kidney disease (CKD). This is most applicable to older individuals with CKD, the majority of whom have a creatinine-based estimated glomerular ... -
Validation of the EULAR/ERA-EDTA recommendations for the management of ANCA-associated vasculitis by disease content experts
(2017)The European League Against Rheumatism recommendations for the management of antineutrophil cytoplasmic antibody-associated vasculitis have been recently published. Unique to recommendation development, they were also voted ... -
The European Vasculitis Society 2016 Meeting Report
(2017)The 2016 European Vasculitis Society (EUVAS) meeting, held in Leiden, the Netherlands, was centered around phenotypic subtyping in antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV). There were parallel ... -
NK cells in childhood obesity are activated, metabolically stressed, and functionally deficient
(2017)Childhood obesity is a major global concern, with over 50 million children now classified as obese. Obesity has been linked to the development of numerous chronic inflammatory diseases, including type 2 diabetes and multiple ... -
Kidney Function Estimated From Cystatin C, But Not Creatinine, Is Related to Objective Tests of Physical Performance in Community-Dwelling Older Adults
(2017)Background: The burden of chronic kidney disease is highest among older adults but the significance of a diminished level of kidney function in this heterogeneous population is poorly understood. We sought to examine ... -
Genetic effects influencing risk for major depressive disorder in China and Europe
(2017)Major depressive disorder (MDD) is a common, complex psychiatric disorder and a leading cause of disability worldwide. Despite twin studies indicating its modest heritability (~30–40%), extensive heterogeneity and a complex ... -
Virtual brain biopsies in amyotrophic lateral sclerosis: diagnostic classification based on in vivo pathological patterns
(2017)Background: Diagnostic uncertainty in ALS has serious management implications and delays recruitment into clinical trials. Emerging evidence of presymptomatic disease-burden provides the rationale to develop diagnostic ... -
From first symptoms to diagnosis of amyotrophic lateral sclerosis: Perspectives of an Irish informal caregiver cohort - A thematic analysis
(2017)Objectives: Informal caregivers play an integral part in the management of amyotrophic lateral sclerosis (ALS). The objective of this study was to explore the journey from first problem symptoms to diagnosis from the ... -
Genetic testing in ALS: A survey of current practices
(2017)Objective: To determine the degree of consensus among clinicians on the clinical use of genetic testing in amyotrophic lateral sclerosis (ALS) and the factors that determine decision-making. Methods: ALS researchers ... -
Survival prediction in Amyotrophic lateral sclerosis based on MRI measures and clinical characteristics
(2017)Background: Amyotrophic lateral sclerosis (ALS) a highly heterogeneous neurodegenerative condition. Accurate diagnostic, monitoring and prognostic biomarkers are urgently needed both for individualised patient care and ... -
Can bacterial virulence factors predict antibiotic resistant Helicobacter pylori infection?
(2018)AIM: To evaluate the association between virulence factor status and antibiotic resistance in Helicobacter pylori (H. pylori)-infected patients in Ireland. METHODS: DNA was extracted from antral and corpus biopsies ... -
Effect of Area-Level Socioeconomic Deprivation on Risk of Cognitive Dysfunction in Older Adults.
(2018)OBJECTIVES: To investigate the relationship between area‐level deprivation and risk of cognitive dysfunction. DESIGN: Cross‐sectional analysis. SETTING: The Trinity, Ulster, and Department of Agriculture (TUDA) ... -
Should vitamin B12 status be considered in assessing risk of neural tube defects?
(2018)There is a strong biological premise for including vitamin B12 with folic acid in strategies to prevent neural tube defects (NTDs), due to the closely interlinked metabolism of these two vitamins. For example, reduction ... -
Unconjugated secondary bile acids activate the unfolded protein response and induce golgi fragmentation via a src-kinase-dependant mechanism
(2017)Bile acids are components of gastro-duodenal refluxate and regarded as causative agents in oesophageal disease but the precise mechanisms are unknown. Here we demonstrate that a specific subset of physiological bile acids ... -
Generation of sinapinic-acid containing extracts from irish rapeseed meal and characterisation of their bioactive properties for potential human health applications
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Rapeseed is one of the world’s major oilseeds, and Europe is the largest producer. During the extraction of the oil, a low economic- value by-product, rapeseed meal, is produced. Rapeseed meal is ordinarily used as an ... -
Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis
(2011)Objectives: To investigate a shared genetic aetiology for skin involvement in psoriasis and psoriatic arthritis (PsA) by genotyping single-nucleotide polymorphisms (SNPs), reported to be associated in genome-wide ... -
Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort
(2012)Objective: A number of rheumatoid arthritis (RA) susceptibility genes have been identified in recent years. Given the overlap in phenotypic expression of synovial joint inflammation between RA and psoriatic arthritis (PsA), ...
