Clinical Medicine: Recent submissions
Now showing items 301-320 of 1003
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Osteoporosis in adults with axial spondyloarthritis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Osteoporosis was the most prevalent comorbidity in individuals with axial spondyloarthropathy (axSpA) in a large multinational study. Ireland was not included in that study, so it was unknown if the profile of comorbidities ... -
Harmonic and superparamagnetic nanoparticles for biomedical imaging and diagnostic applications
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Diagnosing certain diseases and tracking their progression requires the ability to 'see' into the body. This is typically achieved by taking advantage of intrinsic contrast in biological tissues (such as in X-ray or magnetic ... -
Assessing the potential of iron oxide nanoparticles to treat cancer through magnetic hyperthermia
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)5-year survival for pancreatic cancer is about 10% worldwide. A subset of this cancer, pancreatic ductal adenocarcinoma (PDAC), is estimated to become the second leading cause of cancer-related deaths in the US by 2030. ... -
Autosomal dominant tubulointerstitial kidney disease (ADTKD) in Ireland.
(2019)Introduction: Autosomal dominant tubulointerstitial kidney disease (ADTKD) is a rare genetic cause of renal impairment resulting from mutations in the MUC1, UMOD, HNF1B, REN, and SEC61A1 genes. Neither the national or ... -
The complications of vasculitis and its treatment
(2018)Survival following a diagnosis of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) has improved since the introduction of cyclophosphamide-based immunosuppressive regimens and is now almost 80% at 5 ... -
Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status
(2019)Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disease of unknown cause. 30% of patients have anti-neutrophil cytoplasmic antibodies (ANCA) specific for myeloperoxidase (MPO). Here, we describe ... -
Efficacy and Safety of Belimumab and Azathioprine for Maintenance of Remission in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Randomized Controlled Study
(2019)Objective: To evaluate the safety and efficacy of belimumab as adjunctive therapy to maintain remission in antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV). Methods: In this multicenter, ... -
Dye-based chromoendoscopy following polypectomy reduces incomplete polyp resection.
(2020)Background and study aims: The completeness of a polyp resection is an important determinant of quality in colonoscopy, and may reduce incidence of interval cancers. Incomplete resection rates (IRR) vary widely and range ... -
Differential expression of mitochondrial energy metabolism profiles across the metaplasia-dysplasia-adenocarcinoma disease sequence in Barrett?s oesophagus?.
(2014)Contemporary clinical management of Barrett's oesophagus has highlighted the lack of accurate predictive markers of disease progression to oesophageal cancer. This study aims to examine alterations in mitochondrial energy ... -
Diabetes and Brain Health
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Introduction: Type 2 diabetes mellitus (T2DM), one of the most common non-communicable diseases in the world, is linked to multi-organ complications. Such complications include cognitive impairment, dementia and depression. ... -
Innate lymphoid cells and parasites: Ancient foes with shared history
(2018)This special issue of Parasite Immunology charts the rapid advances made in our understanding of the myriad interactions between innate lymphoid cells and parasites and how these interactions have shaped our evolutionary ... -
Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells
(2018)The local regulation of type 2 immunity relies on dialog between the epithelium and the innate and adaptive immune cells. Here we found that alarmin-induced expression of the co-stimulatory molecule OX40L on group 2 innate ... -
IL-1 family cytokine regulation of vascular permeability and angiogenesis
(2019)The IL-1 family of cytokines are well-known for their primary role in initiating inflammatory responses both in response to and acting as danger signals. It has long been established that IL-1 is capable of simultaneously ... -
Dysregulated claudin-5 cycling in the inner retina causes retinal pigment epithelial cell atrophy
(2019)Age-related macular degeneration (AMD) is the leading cause of central retinal vision loss worldwide, with an estimated 1 in 10 people over the age of 55 showing early signs of the condition. There are currently no forms ... -
Low Density Granulocytes in ANCA Vasculitis Are Heterogenous and Hypo-Responsive to Anti-Myeloperoxidase Antibodies
(2019)Low Density Granulocytes (LDGs), which appear in the peripheral blood mononuclear cell layer of density-separated blood, are seen in cancer, sepsis, autoimmunity, and pregnancy. Their significance in ANCA vasculitis (AAV) ... -
Editorial: IL-1 Family Members in Health and Disease
(2019)In 1985, two distinct cDNAs encoding proteins sharing human Interleukin-1 (IL-1) activity were described, thus defining the first two members of the IL-1 family—IL-1α and IL-1β. These potent pro-inflammatory cytokines have ... -
Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction.
(2019)Members of the interleukin-1 (IL-1) family are important mediators of obesity and metabolic disease and have been described to often play opposing roles. Here we report that the interleukin-36 (IL-36) subfamily can play a ... -
Gastrointestinal manifestations in a patient with common variable immunodeficiency syndrome.
(2019)A 57 yo male with a background history of common variable Immunodeficiency syndrome (CVID) on Immunoglobulin Infusion (Kiovig) 40mg three weekly was referred for investigation of diarrhoea and follow up from previous history ... -
Comparisons of Guidelines and Recommendations on Managing Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
(2018)Antineutrophil cytoplasmic antibodies−associated vasculitis (AAV) is associated with high morbidity or mortality, especially if not promptly diagnosed and treated. Many inroads have been made in the understanding of the ... -
CD3ε Expression Defines Functionally Distinct Subsets of Vδ1 T Cells in Patients With Human Immunodeficiency Virus Infection.
(2018)Human γδ T cells expressing the Vδ1 T cell receptor (TCR) recognize self and microbial antigens and stress-inducible molecules in a major histocompatibility complex-unrestricted manner and are an important source of innate ...
