Clinical Medicine: Recent submissions
Now showing items 321-340 of 1003
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siRNA Library Screening Identifies a Druggable Immune-Signature Driving Esophageal Adenocarcinoma Cell Growth
(2018)This study de fi nes immune-associated factors supportive of esophageal adenocarcinoma cell growth through small interfering RNA screening and pathologic and functional studies. Fostamatinib R788, targeting Janus ... -
Phosphorylation of Rab5a protein by protein kinase Cϵ Is crucial for T-cell migration
(2014)Rab GTPases control membrane traffic and receptor-mediated endocytosis. Within this context, Rab5a plays an important role in the spatial regulation of intracellular transport and signal transduction processes. Here, we ... -
RACK1 to the future – a historical perspective.
(2013)This perspective summarises the first and long overdue RACK1 meeting held at the University of Limerick, Ireland, May 2013, in which RACK1 ’ s role in the immune system, the heart and the brain were discussed and ... -
Regulating the Regulator: Phosphorylation of PKC θ in T Cells.
(2012)Protein kinase C θ (PKC θ) is a serine/threonine kinase that is now firmly established as a central component in T cell activation, proliferation, differentiation, and apoptosis (Hayashi and Altman, 2007). Since it was ... -
Leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction induces a novel genetic signature resulting in T-cells refractory to transforming growth factor-β signaling.
(2012)The immunesuppressive cytokine TGF-β plays crucial regulatory roles in the induction and maintenance of immunologic tolerance and prevention of immunopathologies. However, it remains unclear how circulating T-cells can ... -
Deoxycholic acid impairs glycosylation and fucosylation processes in esophageal epithelial cells.
(2012)It is generally accepted that esophageal adenocarcinoma arises from a Barrett's metaplastic lesion. Altered glycoprotein expression has been demonstrated in tissue from patients with Barrett's esophagus and esophageal ... -
Hepatitis C virus targets the T cell secretory machinery as a mechanism of immune evasion.
(2011)T cell activation and the resultant production of interleukin (IL-2) is a central response of the adaptive immune system to pathogens, such as hepatitis C virus (HCV). HCV uses sev- eral mechanisms to evade both the ... -
Bile acids modulate the Golgi membrane fission process via a protein kinase Ceta and protein kinase D-dependent pathway in colonic epithelial cells.
(2010)Deoxycholic acid (DCA) is a secondary bile acid that modulates signalling pathways in epithelial cells. DCA has been implicated in pathogenesis of colon carcinoma, particularly by activation of the protein kinase C (PKC) ... -
STAT3 knockdown by siRNA induces apoptosis in human cutaneous T-cell lymphoma line Hut78 via downregulation of Bcl-xL
(2010)Cutaneous T-cell lymphomas (CTCLs) are non-Hodgkin's lymphomas resulting from clonal expansion and localization of malignant T-lymphocytes to the skin. CTCL cells have defective ... -
The Development and Application of a Novel Method for the Quantification of Prebeta-1 HDL in Plasma
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Prebeta-1 HDL was one of the distinct molecular subspecies of HDL identified in the mid to late eighties . It is, now recognised as having a pivotal role in reverse cholesterol transport accounting for up to 90% of cholesterol ... -
Adaptive immune response in human Staphylococcus aureus bloodstream infection
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Staphylococcus aureus bloodstream infection is a common and life-threatening condition. Treatment outcomes are poor, suboptimal clinical management is common, antimicrobial resistance continues to emerge, and there are few ... -
Healthy Eating, Food Safety and Food Legislation: A Guide Supporting the Healthy Ireland Food Pyramid
(2019)This guide provides extended information to support the Healthy Ireland Food Pyramid 2016, which is based on international best practice and tailored to meet the specific needs of Ireland’s population. These healthy ... -
High Prevalence of Antibiotic Resistance in Iranian Helicobacter pylori Isolates: Importance of Functional and Mutational Analysis of Resistance Genes and Virulence Genotyping
(2019)The high prevalence of antibiotic resistance in Helicobacter pylori has become a great challenge in Iran. The genetic mutations that contribute to the resistance have yet to be precisely identified. This study aimed to ... -
?Examining the connectivity between different cellular processes in the Barrett tissue microenvironment: energy metabolism, hypoxia, inflammation, p53 and obesity?.
(2016)In Barrett associated tumorigenesis, oxidative phosphorylation and glycolysis are reprogrammed early in the disease sequence and act mutually to promote disease progression. However, the link between energy metabolism and ... -
The Mitochondrial Genes BAK1, FIS1 and SFN are Linked with Alterations in Mitochondrial Membrane Potential in Barrett?s Esophagus
(2018)Barrett’s esophagus and esophageal cancer lack prognostic markers that allow the tailoring of personalized medicine and biomarkers with potential to provide insight into treatment response. This study aims to characterize ... -
Modulating Iron for Metabolic Support of TB Host Defense
(2018)Tuberculosis (TB) is the world's biggest infectious disease killer. The increasing prevalence of multidrug-resistant and extensively drug-resistant TB demonstrates that current treatments are inadequate and there is an ... -
Vascular disease is associated with the expression of genes for intestinal cholesterol transport and metabolism
(2017)Context: Intestinal cholesterol metabolism is important in influencing postprandial lipoprotein concentrations, and might be important in the development of vascular disease. Objective: This study evaluated associations ... -
?Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival?.
(2016)Despite extensive efforts, cancer therapies directed at the Protein Kinase C (PKC) family of serine/threonine kinases have failed in clinical trials. These therapies have been directed at inhibiting PKC and have, in some ... -
'Altered Mitochondrial Function and Energy Metabolism Is Associated with a Radioresistant Phenotype in Oesophageal Adenocarcinoma'.
(2014)Neoadjuvant chemoradiation therapy (CRT) is increasingly the standard of care for locally advanced oesophageal cancer. A complete pathological response to CRT is associated with a favourable outcome. Radiation therapy is ... -
?Dysregulated bioenergetics: a key regulator of joint inflammation?.
(2016)Objectives: This study examines the relationship between synovial hypoxia and cellular bioenergetics with synovial inflammation. Methods: Primary rheumatoid arthritis synovial fibroblasts (RASF) were cultured with ...
