Clinical Medicine: Recent submissions
Now showing items 561-580 of 1003
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Epidemiology of lung cancer in the Republic of Ireland
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2005)The study aimed at investigating the epidemiology of overall lung cancer pattern in the Republic of Ireland across different time-periods. The study also examined the lung cancer incidence pattern across major cell-types ... -
Interrogation of PI3K inhibition strategies in non-small cell lung cancer (NSCLC)
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2014)Lung cancer is the leading cause of cancer related death in Ireland and much of the Western world. Despite advances in anti-cancer therapies, the overall 5 year survival for lung cancer remains poor, at less than 15%. As ... -
Application of probabilistic modelling to food chemical exposure assessments
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2004)Risk assessment of food chemical intake is at the core of food safety policy within the EU and the assessment of food chemical exposure is an integral part of the risk assessment process. There is an increasing demand to ... -
Particulate air pollution and mortality in Dublin 1980-1996
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2000)Air pollution in Dublin was studied for the period from 1980 to 1996. The factors which contribute to air pollution were investigated, and the nature of particulate air pollution is discussed. The trends in air pollution, ... -
Investigating protein and gene biomarker expression, specifically chemokine (C-X-C motif) ligand 16 (CXCL16), associated with cardiovascular diseases using a combination of in vitro and in vivo techniques
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2014)A patient based study was designed to analyze serum concentrations of 10 known inflammatory markers, GM-CSF, IFN-γ, IL-10, IL-12p70,IL-1β, IL-2, IL-6, IL-8, TNF-a and CXCL16 in asymptomatic and symptomatic pre-operative ... -
The role of HIF-lalpha and hypoxia in the preferential response of prostate tumours to microtubule-targeting agents
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)Tumour hypoxia is emerging as a common feature of prostate tumours associated with poor prognosis mainly due to their resistance to chemo- radiotherapy regimes. The efficacy of microtubule-targeting agents (MTAs) has ... -
An enhanced in vivo stable isotope labeling by amino acids in cell culture (SILAC) model for quantification of drug metabolism enzymes.
(2015)Many of the enzymes involved in xenobiotic metabolism are maintained at a low basal level and are only synthesized in response to activation of upstream sensor/effector proteins. This induction can have implications in a ... -
Ligation of TLR7 on CD19(+) CD1d(hi) B cells suppresses allergic lung inflammation via regulatory T cells.
(2015)B cells have been described as having the capacity to regulate cellular immune responses and suppress inflammatory processes. One such regulatory B-cell population is defined as IL-10-producing CD19(+) CD1d(hi) cells. ... -
Vascular endothelial growth factor is an autocrine growth factor, signaling through neuropilin-1 in non-small cell lung cancer
(2015)BACKGROUND: The VEGF pathway has become an important therapeutic target in lung cancer, where VEGF has long been established as a potent pro-angiogenic growth factor expressed by many types of tumors. While Bevacizumab ... -
Bcl11b is essential for group 2 innate lymphoid cell development
(2015)Group 2 innate lymphoid cells (ILC2s) are often found associated with mucosal surfaces where they contribute to protective immunity, inappropriate allergic responses, and tissue repair. Although we know they develop from ... -
Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity.
(2015)Atopic dermatitis (AD) is an inflammatory skin condition that can occur in early life, predisposing to asthma development in a phenomenon known as the atopic march. Although genetic and environmental factors are known to ... -
Cytokine polymorphisms in the study of Helicobacter pylori related gastric pathology
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2005)Persistent local inflammation is now accepted as a risk factor in the development of a number of cancers. Non-cardia gastric cancer is thought to develop after a long lead-time whereby persistent inflammation, caused by ... -
An investigation of risk factors for fracture in patients with osteoporosis and osteopaenia using biomechanical, biochemical and radiological assessments
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Osteoporosis is defined as a skeletal disorder characterised by compromised bone strength resulting in an increased risk for fracture. Hip fractures are the most common osteoporotic fracture in older adults and occur due ... -
Biomechanical measures of function of the ano-rectal region of the human body
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2015)In this research, the Functional Lumen Imaging Probe (FLIP), a novel measurement tool, was adapted to measure the biomechanical properties and morphological changes of the ano-rectal region during distension and provocative ... -
Development of an automated MRI-based diagnostic protocol for amyotrophic lateral sclerosis using disease-specific pathognomonic features: A quantitative disease-state classification study
(2016)Background Despite significant advances in quantitative neuroimaging, the diagnosis of ALS remains clinical and MRI-based biomarkers are not currently used to aid the diagnosis. The objective of this study is to develop ... -
Caregiving in ALS - A mixed methods approach to the study of Burden
(2016)Background Caregiver burden affects the physical, psychological and emotional well-being of the caregiver. The purpose of this analysis was to describe an informal caregiver cohort (n = 81), their subjective assessment ... -
High content analysis of cellular localisation and biocompatibility of CdTe and CdSe / ZnS nanoparticles
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)The rules governing particle properties at the nanoscale relate more to the laws of quantum mechanics than classical mechanics. Biologists have been keen to harness nanoparticles not only for these properties but also ...
