Clinical Medicine: Recent submissions
Now showing items 581-600 of 1003
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Investigations into the role of mast cell mediated effects on the intestinal epithelial barrier in vitro : implications for the pathogenesis of irritable bowel syndrome
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2013)Irritable bowel syndrome (IBS) is a highly prevalent functional bowel disorder characterised by abdominal pain or discomfort and associated with altered bowel habit, abdominal bloating and disturbed defecation. The aetiology ... -
Microtubule associated signal transduction processes in t-cell migration
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)The ordered, directional migration of T-lymphocytes is a key process during immune surveillance, and immune response. T-cell migration is a complex, highly coordinated process. This requires cell adhesion to the high ... -
Genetic studies in coeliac disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)This study is primarily concerned with elucidating genetic contributions to coeliac disease in the Irish population via case control based association studies. Due to the nature of complex diseases, and the large sample ... -
Investigation of lymph node transplantation as therapy for breast cancer related lymphedema
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2009)Humans have hundreds of lymph nodes, collections of which are found in the underarms, groin, neck, chest, and abdomen. They have long been considered 'neutral' elements in terms of lymph transport. An assumption has always ... -
Mechanisms of human innate immune cell death and consequent adaptive immune responses during Mycobacterium tuberculosis infection
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012)Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, is a highly successful pathogen, infecting an estimated one-third of the global population. Mtb infection leads to the deaths of approximately 1.3 ... -
Vitamin B12 in the elderly and its relationship to cognition, falls and balance, mood and mortality
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Observational studies to date have provided conflicting evidence with respect to the clinical relevance of vitamin B12 status in elderly patients. The aims of this work were to establish the relationship of vitamin B12 ... -
Ursodeoxycholic acid : a molecular modulator of the inflammation-carcinoma sequence in the oesophagus?
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012)Gastro-oesophageal reflux disease (GORD) is a prevalent disease, affecting up to 20% of the western population. In up to 10% of these patients Barrett’s Oesophagus (BO) will exist. This nietaplastic epithelium carries a ... -
Cytokine expression in coronary artery disease : high sensitivity detection in a patient cohort and analysis of its effect on cardiac myoblast cells in an in vitro model
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Cardiovascular disease has evolved into one of the major causes of death in the developed world. Common clinical presentations of the disease are Acute Coronary Syndromes (ACS), Heart Failure, Carotid disease, Abdominal ... -
Undernutrition in inactive and mildly active Crohn's Disease : an unrecognised problem?
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2009)Crohn's disease (CD), the incidence of which is increasing worldwide, is a chronic transmural inflammatory disease that can affect any part of the gastrointestinal tract. It follows a relapsing remitting course and results ... -
Genomic characterisation and comparative proteome analysis of Helicobacter pylori related gastroduodenal pathologies
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2009)The Gram-negative bacterium Helicobacter pylori is a gastric pathogen that chronically infects more than half the world’s population. H. pylori infection induces various upper gastro- duodenal diseases, and there is a ... -
Renal function, cardiovascular disease and long term outcome in different cohorts of the Glasgow population
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Over the past ten to fifteen years, the interaction between cardiovascular disease and chronic kidney disease (CKD) has come under increased scrutiny. Traditional cardiovascular risk factors are also associated with the ... -
Protein Kinase C : a key enzyme in mediating interferon-a signalling and a new player in its activity against Hepatitis C infection
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2013)The hepatitis C virus (HCV) is a major cause of chronic liver cirrhosis and hepatocellular carcinoma (Lauer and Walker, 2001). The World Health Organisation estimates that there are 170 million individuals infected globally, ... -
Changes in urinary metabolomic profile during relapsing renal vasculitis
(2016)Current biomarkers of renal disease in systemic vasculitis lack predictive value and are insensitive to early damage. To identify novel biomarkers of renal vasculitis flare, we analysed the longitudinal urinary metabolomic ... -
Pauci Immune crescentic glomerulonephritis in a patient with T-cell lymphoma and argyria
(2016)Background: Silver is a transition metal, toxic when ingested in significant amounts, causing argyria (skin deposition) and argyrosis (eye deposition). It is excreted mainly via the gastrointestinal tract with only small ... -
Anti-proteinase 3 anti-neutrophil cytoplasm autoantibodies recapitulate systemic vasculitis in mice with a humanized immune system.
(2012)Evidence is lacking for direct pathogenicity of human anti-proteinase-3 (PR3) antibodies in development of systemic vasculitis and granulomatosis with polyangiitis (GPA, Wegener's granulomatosis). Progress in study of these ... -
The role of novel risk markers in cardiovascular disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Cardiovascular disease (CVD) is the leading cause of death in Ireland and globally. Conventional risk factors such as blood pressure, cholesterol and smoking account for most of CVD. A small but significant residual risk ... -
Cutaneous changes in renal transplant recipients - is there a relationship between benign and malignant disease?
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2009)Renal transplant recipients are at an increased risk of many cutaneous diseases. The increased incidence of cutaneous malignancy is well recognised. Cutaneous infections and iatrogenic effects of immunosuppressive medications ... -
Cardiovascular risk in non-diabetes mellitus insulin resistant states
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012)This thesis explores the various cardiovascular risks that occur in insulin resistant states apart from type 2 diabetes mellitus (T2DM). Various cardiovascular risk markers and metabolic derangements related to cardiovascular ... -
Barrett's oesophagus and associated cancer : the influence of bile acid regulated genetic factors and intestinal transcription factors in the pathogenesis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012)Gastrooesophageal reflux disease (GORD) is very common and it is estimated that up to 20% of the western population will experience weekly heartburn. The initial simple mucosal damage can lead to further complications like ... -
Studies on methotrexate cytotoxicity and apoptosis in human B-lymphocyte cell lines : with emphasis on 5,10-methylenetetrahydrofolate reductase 677C→T genotype and folate status
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Methotrexate (Mtx) is an antifolate drug which is widely used in treatment of cancer and of autoimmune and inflammatory conditions. The main mechanism by which Mtx operates is inhibition of dihydrofolate reductase (DHFR), ...
