Clinical Medicine: Recent submissions
Now showing items 601-620 of 1003
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The role of insulin-like growth factor 1 receptor (IGF-IR) in non-small cell lung cancer (NSCLC)
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012)Lung cancer is the most common cause of cancer related death in Ireland and worldwide. Despite modest advances in traditional cytotoxic chemotherapy, survival rates remain disappointing at approximately 15%. Targeted ... -
Characterisation of nanoparticle distribution, intergrity and toxicity in vivo and in vitro using advanced spectroscopic and microscopic approaches
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012)Much uncertainty surrounds the potential toxicity of new engineered nanomaterials to human health and the environment, either during manufacture, use or at the end of their life cycle. The current generalised methodologies ... -
Ocular Microtremor as a clinical and scientific tool in neurologic disease : validation and application of a generalised discovery protocol
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Ocular microtremor (OMT) , a high frequency low amplitude eye movement, is one of three fixational eye movements present even when the eyes are apparently at rest. The tremor is thought to be related to tonic neural ... -
Vascular correlates of cognitive performance in a community based elderly population
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)Population studies suggest that cardiovascular risk factors may be associated with cognitive impairment. Epidemiological studies evaluating individual markers of vascular disease as a risk factor for cognitive dysfunction ... -
Type 2 diabetes, insulin resistance and effects of exercise in young adults
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)Study 1- Characteristics of the physically active but insulin resistant phenotype. Methods: Data from the European Group on Insulin Resistance- Relationship between Insulin Sensitivity and Cardiovascular Risk study was ... -
Bile acids and Barrett's oesophagus : the development of a functional siRNA screen to identify novel therapeutic targets
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)The development of oesophageal adenocarcinoma (OAC) occurs in a setting of chronic reflux known as gastro-oesophageal reflux disease (GORD) and with a recognised premalignant lesion, Barrett’s oesophagus (BO). BO is ... -
An investigation into novel components and signalling mechanisms of inflammasomes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)This thesis concerns an analysis of caspase-1 and ASC, key components of the inflammasome. At the outset Rab39a had been found in a complex with caspase-1. Rab39a is a member of the Rab GTPase family, a group of proteins ... -
Ocular microtremor measurement, characterization & analysis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)Ocular Microtremor (OMT) is a high frequency tremor of the eye present in all normal subjects even if the eye is apparently still. It is one of the fixational eye movements. Changes in the OMT frequency and pattern have ... -
Targeted polyethylene glycol gold nanoparticles for the treatment of pancreatic cancer: from synthesis to proof-of-concept in vitro studies.
(2016)Abstract: The main objective of this study was to optimize and characterize a drug delivery carrier for doxorubicin, intended to be intravenously administered, capable of improving the therapeutic index of the chemotherapeutic ... -
Towards a nanospecific approach for risk assessment.
(2016)In the current paper, a new strategy for risk assessment of nanomaterials is described, which builds upon previous project outcomes and is developed within the FP7 NANoREG project. NANoREG has the aim to develop, for the ... -
Proinflammatory Effects of Pyrogenic and Precipitated Amorphous Silica Nanoparticles in Innate Immunity Cells.
(2016)Amorphous silica nanoparticles (ASNP) can be synthetized via several processes, 2 of which are the thermal route (to yield pyrogenic silica) and the wet route from a solution containing silicate salts (to obtain precipitated, ... -
Differential stress reaction of human colon cells to oleic-acid-stabilized and unstabilized ultrasmall iron oxide nanoparticles
(2014)Therapeutic engineered nanoparticles (NPs), including ultrasmall superparamagnetic iron oxide (USPIO) NPs, may accumulate in the lower digestive tract following ingestion or injection. In order to evaluate the reaction of ... -
Patterns of Transcriptional Response to 1,25-Dihydroxyvitamin D3 and Bacterial Lipopolysaccharide in Primary Human Monocytes.
(2016)The active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25D), plays an important immunomodulatory role, regulating transcription of genes in the innate and adaptive immune system. The present study examines patterns of ... -
The Frontal Assessment Battery: Normative Performance in a Large Sample of Older Community-Dwelling Hospital Outpatient or General Practitioner Attenders
(2016)Background: The Frontal Assessment Battery (FAB) is a short battery designed to assess frontal executive functioning, but data for interpretation of performance are limited. Objectives: The Trinity, Ulster, Department ... -
A Common Polymorphism in HIBCH Influences Methylmalonic Acid Concentrations in Blood Independently of Cobalamin
(2016)Methylmalonic acid (MMA) is a by-product of propionic acid metabolism through the vitamin B12 (cobalamin)-dependent enzyme methylmalonyl CoA mutase. Elevated MMA concentrations are a hallmark of several inborn errors of ... -
Determinants of 25-hydroxyvitamin D in older Irish adults.
(2015)Background: vitamin D deficiency is prevalent in older adults living in Northern Europe and is influenced by several factors which may vary significantly with age. Objective: we aimed to investigate the determinants of ... -
Dairy intakes in older Irish adults and effects on vitamin micronutrient status: Data from the TUDA study
(2016)Consumption of dairy products has been associated with positive health outcomes including a lower risk of hypertension, improved bone health and a reduction in the risk of type 2 diabetes. The suggested dairy intake for ... -
A time transect of exomes from a Native American population before and after European contact
(2016)A major factor for the population decline of Native Americans after European contact has been attributed to infectious disease susceptibility. To investigate whether a pre-existing genetic component contributed to this ... -
Single Agent Antihypertensive Therapy and Orthostatic Blood Pressure Behaviour in Older Adults Using Beat-to-Beat Measurements: The Irish Longitudinal Study on Ageing.
(2016)Background Impaired blood pressure (BP) stabilisation after standing, defined using beat-to-beat mea- surements, has been shown to predict important health outcomes. We aimed to define the relationship between individual ... -
An in vivo study of utricular hair cell degeneration and regeneration following animoglycoside induced damage of the mammalian inner ear
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2007)The anatomy of the mammalian ear is similar between the different subspecies. This applies to the structure of the utricle in humans and in guinea pigs. Hence the choice of the guinea pig utricle allows any findings ...
