Clinical Medicine: Recent submissions
Now showing items 621-640 of 1003
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The application of metabolomics to human nutrition research
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)Background: Recent developments in analytical technologies and bioinformatics are driving modem advances in biological research. Many of these methods will have particular relevance in the field of nutrition. Among these ... -
The effects of dietary fat and genotype on insulin sensitivity : the LIPGENE Dietary Intervention Study
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)The Metabolic Syndrome (MetS) is characterised by hyperinsulinaemia, low glucose tolerance, dyslipidaemia (increased triacylglycerol, (TAG) and non-esterified fatty acids (NEFA) and reduced high density lipoprotein ... -
C5L2, a nonsignalling C5A receptor is uncoupled to G proteins
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)The complement anaphylatoxins are prominent mediators of host defence and inflammation. The small subunit of the fifth component of complement, C5a has complex effects in vivo including potential anti- and pro-inflammatory ... -
Translating molecular approaches for the detection and evaluation of minimal residual disease kinetics in childhood acute lymphoblastic leukaemia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)Childhood acute lymphoblastic leukaemia (ALL) is the leading cause of cancer-linked mortality identified in children. Approximately 80% of patients are successfully treated. However, 20-25% of patients will still go on to ... -
Investigating novel targets of DNA methylation for the early detection of prostate cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2007)Prostate cancer is an escalating international health problem. It is the most common non- cutaneous malignancy and the second leading cause of cancer related deaths in men in the Western world. Like many other cancers, ... -
Mechanisms of immune evasion utilised by the Hepatitis C virus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2009)Hepatitis C virus (HCV) is a small, enveloped RNA virus which is distributed worldwide and according to the WHO the number of infected individuals is estimated to be approximately 170 million. HCV creates a heavy burden ... -
Cytokine gene expression, protein expression and genetic variability in the human response to infection
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)In this thesis I explore the hypothesis that a pro-inflammatory cytokine immune response is a beneficial and protective host mechanism in the setting of the human response to infection. The various regulatory pathways ... -
Clinicopathological and inflammatory prognostic factors in non-small cell lung cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)Lung cancer is the most common cause of cancer death worldwide. Despite improvements in diagnosis and treatments, the overall prognosis for patients with lung cancer remains poor and novel therapeutic approaches are required. ... -
Investigating the role of DNA hypermethylation as a key controller of aberrant cell death in prostate cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)Prostate cancer remains a global public health problem. Worldwide, it is the most common noncutaneous cancer in men and is a leading cause of cancer- related deaths among men in North America and Westem\Northem Europe. ... -
Effects of polyunsaturated fatty acids on mediators of inflammation associated with atherosclerosis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)The inflammatory pathogenesis of atherosclerosis has been defined, largely by the “response to injury” hypothesis. The morphological development of atherosclerosis has also been defined. Monocytes and lymphocytes accumulate ... -
Proteomic and cell based approaches for the study of the intestinal epithelial response to Helicobacter pylori soluble components in an ex vivo model of ulcerogenesis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)The aim of the present study was to investigate the effects of secreted components of the gastrointestinal pathogen H. pylori on the duodenal epithelium in humans. The effects of H. pylori are not only mediated by direct ... -
Intestinal microsomal triglyceride transfer protein, promoter region polymorphisms and postprandial lipoproteins in Type 2 Diabetes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2007)Microsomal triglyceride transfer protein is an ancient lipid transfer protein responsible for the assembly of chylomicrons in the intestine and very low density lipoproteins in the liver. Common MTP gene promoter region ... -
Conjugated lineolic acid and insulin sensitivity : insights from metabolic and molecular markers
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)Insulin resistance signifies an impaired biological response to insulin, and usually implies resistance to the effects of insulin on glucose uptake, metabolism, or storage. This defect is commonly observed in type 2 diabetes ... -
The interaction between dietary fatty acids and inflammation on insulin sensitivity
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)The metabolic syndrome (MetS) has been defined as a multi-component disorder consisting of a combination of metabolic abnormalities associated with an increased risk of developing type 2 diabetes mellitus (T2DM) and ... -
Colorectal cancer screening
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)Colorectal cancer is a major public health burden and is the most common cause of mortality from cancer in Europe. Over the last two decades robust evidence from randomised clinical trials and case-control series have ... -
The immunogenetics of Hepatitis C Virus in a defined unique cohort
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)Hepatitis C virus is a major cause of liver-related morbidity and mortality worldwide as chronic infection develops in up to 80% of those infected and leads to end-stage liver disease in a significant percentage. The ... -
A promising hypoxia-inducible suicide gene therapy strategy for prostate cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)Gene therapy targeted to hypoxic tumour cells may allow selective killing of malignant cells. The induction of gene expression under hypoxic conditions is governed by the activation of hypoxia-inducible factor 1 and its ... -
A novel protein NFKBIL-1 regulates the activity of key transcription factors
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)Inflammation is a physiological process initiated in response to an injury or infection. Proper execution of the inflammatory response requires activation of several pro- inflammatory transcription factors. Nuclear Factor ... -
Dietary fatty acids and diabetes mellitus : effect on postprandial lipoproteins and apolipoproteins
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2002)This thesis explores the relative merits of dietary polyunsaturated and monounsaturated fat in reducing the postprandial dyslipidaemia which is associated with diabetes. Of particular interest are the apolipoproteins which ... -
Factors modulating TLR2, TLR4 and HBD2 expression in respiratory epithelium in COPD
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)The innate immune response of the respiratory epithelium, employing mechanisms of germ-line encoded, genetically conserved pattern recognition to “non-self’ organisms, is an important component of host defence against ...
