dc.contributor.advisor | Connor, Tom | |
dc.contributor.author | Boyle, Noreen | |
dc.date.accessioned | 2016-12-14T10:25:05Z | |
dc.date.available | 2016-12-14T10:25:05Z | |
dc.date.issued | 2007 | |
dc.identifier.citation | Noreen Boyle, 'Methylenenedioxymethamphetamine (MDMA Ecstasy) suppresses the innate immune system : a critical role for the anti-inflammatory cytokine interleukin-10', [thesis], Trinity College (Dublin, Ireland). Department of Physiology, 2007, pp 227 | |
dc.identifier.other | THESIS 8307 | |
dc.description.abstract | 3,4-methylenedioxymethamphetamine (MDMA; “Ecstasy”) is a ring-substituted phenylisopropylamine and globally abused drug that has been implicated to have immunosuppressive effects in animals and humans. Here MDMA was shown to suppress production of the pro-inflammatory and Th1 promoting cytokine IFN-γ in response to an in vivo lipopolysaccharide (LPS) challenge in mice. Impaired IFN-γ production was accompanied by reduced expression of IL-12 and IL-15; two cytokines involved in IFN-γ induction. MDMA also resulted in impaired IFN-γ signalling, indicated by reduced STAT1 phosphorylation and reduced expression of several IFN-γ inducible molecules, namely the chemokine interferon inducible protein 10 (IP-10), the co-stimulatory molecule CD40, and the enzyme responsible for nitric oxide synthesis, INOS. Furthermore, MDMA down-regulated cell surface expression of MHC class II and the co-stimulatory molecules CD40, ICAM-1 (CD54) and B7.2 (CD86) on dendritic cells and macrophages; these molecules are required for effective antigen presentation, and T-cell activation. Consistent with its ability to interfere with antigen presentation, MDMA suppressed T-cell activation in the mixed lymphocyte reaction (MLR) signifying that the proliferative capacity of stimulator cells was abolished. In addition, MDMA suppressed antigen-specific cytokine responses to the protein antigen KLH. | |
dc.format | 1 volume | |
dc.language.iso | en | |
dc.publisher | Trinity College (Dublin, Ireland). Department of Physiology | |
dc.relation.isversionof | http://stella.catalogue.tcd.ie/iii/encore/record/C__Rb13221315 | |
dc.subject | Physiology, Ph.D. | |
dc.subject | Ph.D. Trinity College Dublin | |
dc.title | Methylenenedioxymethamphetamine (MDMA Ecstasy) suppresses the innate immune system : a critical role for the anti-inflammatory cytokine interleukin-10 | |
dc.type | thesis | |
dc.type.supercollection | thesis_dissertations | |
dc.type.supercollection | refereed_publications | |
dc.type.qualificationlevel | Doctoral | |
dc.type.qualificationname | Doctor of Philosophy (Ph.D.) | |
dc.rights.ecaccessrights | openAccess | |
dc.format.extentpagination | pp 227 | |
dc.description.note | TARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie | |
dc.identifier.uri | http://hdl.handle.net/2262/78286 | |