dc.contributor.advisor | Lynch, Marina | |
dc.contributor.author | Costelloe, Céire E. | |
dc.date.accessioned | 2016-12-14T14:48:51Z | |
dc.date.available | 2016-12-14T14:48:51Z | |
dc.date.issued | 2007 | |
dc.identifier.citation | Céire E. Costelloe, 'Does IL-1F5 have anti-inflammatory actions in the brain?', [thesis], Trinity College (Dublin, Ireland). Department of Physiology, 2007, pp 269 | |
dc.identifier.other | THESIS 8296 | |
dc.description.abstract | Similarity in structure and sequence homology has led to the identification of additional members of the IL-1 ligand and receptor superfamilies. Because of the importance of IL-1 in immune and inflammatory reactions, elucidation of the respective roles of these recently described members is a priority. Thus far identification of a biological role for IL-1F5 has remained elusive. In this thesis investigation into a possible role for IL-1F5 in neuronal tissue was carried out and the findings of this study suggest that IL-1F5 abrogates IL-1β-induced inhibition of Long term potentiation (LTP), and associated increase in activation of c-Jun N terminal kinase (JNK). The data also show that IL-1F5 antagonizes the inhibitory effect of lipopolysaccharide (LPS) on LTP in rat dentate gyrus. The data indicate that this is associated with its ability to inhibit the LPS-induced activation of microglial cells and, as a consequence inhibit the increase in IL-1β and JNK. | |
dc.format | 1 volume | |
dc.language.iso | en | |
dc.publisher | Trinity College (Dublin, Ireland). Department of Physiology | |
dc.relation.isversionof | http://stella.catalogue.tcd.ie/iii/encore/record/C__Rb13219943 | |
dc.subject | Physiology, Ph.D. | |
dc.subject | Ph.D. Trinity College Dublin | |
dc.title | Does IL-1F5 have anti-inflammatory actions in the brain? | |
dc.type | thesis | |
dc.type.supercollection | thesis_dissertations | |
dc.type.supercollection | refereed_publications | |
dc.type.qualificationlevel | Doctoral | |
dc.type.qualificationname | Doctor of Philosophy (Ph.D.) | |
dc.rights.ecaccessrights | openAccess | |
dc.format.extentpagination | pp 269 | |
dc.description.note | TARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie | |
dc.identifier.uri | http://hdl.handle.net/2262/78324 | |