dc.contributor.advisor | Lynch, Marina | |
dc.contributor.author | Denieffe, Stephanie | |
dc.date.accessioned | 2017-01-18T12:21:31Z | |
dc.date.available | 2017-01-18T12:21:31Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Stephanie Denieffe, 'Modulation of microglial phenotypes by CD200', [thesis], Trinity College (Dublin, Ireland). Department of Physiology, 2012, pp 207 | |
dc.identifier.other | THESIS 10029 | |
dc.description.abstract | Microglia are the principal immune cells of the CNS continually surveying their micro-environment for endogenous and exogenous stimuli which may threaten the immunological balance. Recent studies have suggested that activated microglia, like macrophages, adopt different phenotypes depending on the stimulus; IFNy induces classical activation of microglia, whereas IL-4 induces an alternative activation state. A deactivation state has been described in which the interaction between ligand-receptor pairs, for example CD200-CD200R, suppress the immune response. The focus of this study was to investigate the modulatory role of CD200 on different microglial phenotypes. | |
dc.format | 1 volume | |
dc.language.iso | en | |
dc.publisher | Trinity College (Dublin, Ireland). Department of Physiology | |
dc.relation.isversionof | http://stella.catalogue.tcd.ie/iii/encore/record/C__Rb15349590 | |
dc.subject | Physiology, Ph.D. | |
dc.subject | Ph.D. Trinity College Dublin | |
dc.title | Modulation of microglial phenotypes by CD200 | |
dc.type | thesis | |
dc.type.supercollection | thesis_dissertations | |
dc.type.supercollection | refereed_publications | |
dc.type.qualificationlevel | Doctoral | |
dc.type.qualificationname | Doctor of Philosophy (Ph.D.) | |
dc.rights.ecaccessrights | openAccess | |
dc.format.extentpagination | pp 207 | |
dc.description.note | TARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie | |
dc.identifier.uri | http://hdl.handle.net/2262/78883 | |