dc.contributor.advisor | Connor, Thomas | |
dc.contributor.author | Ryan, Karen M. | |
dc.date.accessioned | 2017-02-08T14:37:05Z | |
dc.date.available | 2017-02-08T14:37:05Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | Karen M. Ryan, 'Beta₂-adrenoceptors as modulators of glial immune function', [thesis], Trinity College (Dublin, Ireland). Department of Physiology, 2009, pp 364 | |
dc.identifier.other | THESIS 9321 | |
dc.description.abstract | The endogenous anti-inflammatory and neurotrophic effects of noradrenahne are mediated by β2-adrenoceptors on astrocytes and microglia in the central nervous system (CNS). Notably, clinical studies demonstrate that β2-adrenoceptors are absent from astrocytes of patients with Multiple Sclerosis (MS) and loss of glial β2- adrenoceptors is likely to contribute to the chronic inflammation observed in this disorder. Additionally it has been suggested that a loss of central noradrenergic tone may contribute to the development of Alzheimer’s disease by facilitating the chronic neuroinflammation and amyloid-P deposition which is characteristic of this disease. The biological basis for the loss of β2-adrenoceptors in MS is not known, therefore the possibility that exposure to an inflammatory stimulus could down-regulate glial β2-adrenoceptor expression and responsiveness was examined here. The results demonstrate that in vitro exposure of primary mixed glial cultures to LPS+lFN-y down-regulates β2-adrenoceptor mRNA and cell surface expression (~50%) and reduces the accumulation of intracellular cAMP in response to the β2-adrenoceptor agonist salbutamol, an effect found to be specific to β2- adrenoceptor and not due to an effect on intracellular signaling events. | |
dc.format | 1 volume | |
dc.language.iso | en | |
dc.publisher | Trinity College (Dublin, Ireland). Department of Physiology | |
dc.relation.isversionof | http://stella.catalogue.tcd.ie/iii/encore/record/C__Rb14876560 | |
dc.subject | Physiology, Ph.D. | |
dc.subject | Ph.D. Trinity College Dublin | |
dc.title | Beta₂-adrenoceptors as modulators of glial immune function | |
dc.type | thesis | |
dc.type.supercollection | thesis_dissertations | |
dc.type.supercollection | refereed_publications | |
dc.type.qualificationlevel | Doctoral | |
dc.type.qualificationname | Doctor of Philosophy (Ph.D.) | |
dc.rights.ecaccessrights | openAccess | |
dc.format.extentpagination | pp 364 | |
dc.description.note | TARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie | |
dc.identifier.uri | http://hdl.handle.net/2262/79337 | |