dc.contributor.advisor | Lynch, Marina | |
dc.contributor.author | Barry, Claire E. | |
dc.date.accessioned | 2019-04-29T14:22:21Z | |
dc.date.available | 2019-04-29T14:22:21Z | |
dc.date.issued | 2005 | |
dc.identifier.citation | Claire E. Barry, 'An investigation of the role of c-Jun N-terminal Kinase (JNK) in inflammation-associated cell deterioration in rat hippocampus', [thesis], Trinity College (Dublin, Ireland). Department of Physiology, 2005, pp 309 | |
dc.identifier.other | THESIS 7665 | |
dc.description.abstract | c-Jun N-terminal kinase (JNK) is a milogen-activated protein kinase which is activated in
response to various types of stress (e.g. ischemia, heat shock, osmotic stress, UV
irradiation, and hypoxia). JNK is strongly implicated in mediating detrimental aspects of
inflammatory change across a range of cell types, including that associated with
neuroinflammation. However, definitive evidence of JNK involvement is still lacking,
therefore the objective of these studies was to assess the role of JNK in inflammatory
models in vivo, in particular, its involvement in the impairment of long-term potentiation
(LTP) observed under these conditions. By using direct inhibition of the kinase and two
agents reputed to have antiinflammatory properties, it was intended that the relevance o f
JNK and its associated signalling in mediation of inflammatory change would be
determined. | |
dc.format | 1 volume | |
dc.language.iso | en | |
dc.publisher | Trinity College (Dublin, Ireland). Department of Physiology | |
dc.relation.isversionof | http://stella.catalogue.tcd.ie/iii/encore/record/C__Rb12447637 | |
dc.subject | Physiology, Ph.D. | |
dc.subject | Ph.D. Trinity College Dublin | |
dc.title | An investigation of the role of c-Jun N-terminal Kinase (JNK) in inflammation-associated cell deterioration in rat hippocampus | |
dc.type | thesis | |
dc.type.supercollection | thesis_dissertations | |
dc.type.supercollection | refereed_publications | |
dc.type.qualificationlevel | Doctoral | |
dc.type.qualificationname | Doctor of Philosophy (Ph.D.) | |
dc.rights.ecaccessrights | openAccess | |
dc.format.extentpagination | pp 309 | |
dc.description.note | TARA (Trinity's Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie | |
dc.identifier.uri | http://hdl.handle.net/2262/86205 | |