dc.contributor.advisor | Kelly, Aine | |
dc.contributor.author | Callaghan, Charlotte | |
dc.date.accessioned | 2019-04-29T14:44:33Z | |
dc.date.available | 2019-04-29T14:44:33Z | |
dc.date.issued | 2008 | |
dc.identifier.citation | Charlotte Callaghan, 'An investigation of the role of neurotrophins in recognition memory in the rat', [thesis], Trinity College (Dublin, Ireland). Department of Physiology, 2008, pp 279 | |
dc.identifier.other | THESIS 8408 | |
dc.description.abstract | Acquisition and consolidation of newly-acquired information is essential for
formation of long-lasting memories, and both these processes may share common
signaling pathways. The neurotrophins NGF, BDNF, NTS and NT4 have diverse
functions in the adult brain, including learning and memory. Their biological effects are
elicited by binding to Trk receptors and activation o f the ERK/MAPK pathway or the
PI3K/AKT pathway which is believed to mediate protein synthesis, which has previously
been identified as an essential process in memory formation (Kelly et al., 2003). In this
study we investigated the roles of neurotrophins in both acquisition and consolidation of
recognition memory by using neutralising antibodies against each neurotrophin isoform.
An object recognition task was used to test acquisition and consolidation of
memory; rats were tested 10min and 24hr after training to discriminate experimentally
between acquisition and consolidation respectively. Rats treated with the pan-Trk
antagonist tyrphostin AG879 were unable to discriminate between the novel and the
familiar object at both 10min and 24hr when compared with controls, suggesting Trk
receptor activation is required for both acquisition and consolidation, in contrast, rats
treated with anti-BDNF, anti-NGF and anti-NT4/5 displayed comparable learning to
control rats at the 10min timepoint, but displayed learning impairments 24hr later.
Treatment with anti-NT3 had no effect on learning at either timepoint. | |
dc.format | 1 volume | |
dc.language.iso | en | |
dc.publisher | Trinity College (Dublin, Ireland). Department of Physiology | |
dc.relation.isversionof | http://stella.catalogue.tcd.ie/iii/encore/record/C__Rb13341083 | |
dc.subject | Physiology, Ph.D. | |
dc.subject | Ph.D. Trinity College Dublin | |
dc.title | An investigation of the role of neurotrophins in recognition memory in the rat | |
dc.type | thesis | |
dc.type.supercollection | thesis_dissertations | |
dc.type.supercollection | refereed_publications | |
dc.type.qualificationlevel | Doctoral | |
dc.type.qualificationname | Doctor of Philosophy (Ph.D.) | |
dc.rights.ecaccessrights | openAccess | |
dc.format.extentpagination | pp 279 | |
dc.description.note | TARA (Trinity's Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie | |
dc.identifier.uri | http://hdl.handle.net/2262/86236 | |