Effect of intranasal administration of Semliki Forest virus recombinant particles expressing interferon-beta on the progression of experimental autoimmune encephalomyelitis
Citation:
Kathrina Quinn, 'Effect of intranasal administration of Semliki Forest virus recombinant particles expressing interferon-beta on the progression of experimental autoimmune encephalomyelitis', [thesis], Trinity College (Dublin, Ireland). Department of Microbiology, 2006, pp 313Download Item:
Abstract:
Multiple sclerosis (MS) is an autoimmune demyelinating disease of the CNS,
characterized by the presence of sclerotic lesions throughout the brain. MS is thought to
be a CD4+ T helper 1 disease caused by the infiltration of autoaggressive T cells which
upregulate T helper-1 cytokines such as TNF-a and IFN-y. Much success has been
achieved in the treatment of Relapsing Remitting Multiple Sclerosis (RRMS). It is thought
that the antiproliferative activity of IFN-P may inhibit the expansion of the autoaggressive
T cells in MS, therefore limiting disease progression.
Author: Quinn, Kathrina
Advisor:
Atkins, GregoryPublisher:
Trinity College (Dublin, Ireland). Department of MicrobiologyNote:
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Full text availableKeywords:
Microbiology, Ph.D., Ph.D. Trinity College DublinMetadata
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