Browsing Microbiology (Theses and Dissertations) by Title
Now showing items 58-77 of 87
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Microevolution in Helicobacter pylori
(Trinity College (Dublin, Ireland). Department of Microbiology, 2002)Helicobacter pylori chronically colonises the human gastric mucosa. It is a major cause of chronic active gastritis and peptic ulcer disease and is associated with the development of gastric neoplasia. The population ... -
Molecular analysis of surface proteins of staphylococci
(Trinity College (Dublin, Ireland). Department of Microbiology, 2004)S. lugdunensis is an important human pathogen that causes 44% of coagulase negative staphylococcal native valve endocarditis as well as infections such as osteomyelitis and soft tissue abscesses. S. lugdunensis expresses ... -
Molecular analysis of the interaction between protein A of Staphylococcus aureus and von Willebrand factor
(Trinity College (Dublin, Ireland). Department of Microbiology, 2007)Staphylococcus aureus continues to be a major cause of infection in normal as well as immunocompromised hosts, and the increasing prevalence of highly virulent community acquired methicillin-resistant strains is a public ... -
Molecular characterisation of agn43 and its encoded protein, antigen 43, the major phase-variable outer membrane protein of Escherichia coli
(Trinity College (Dublin, Ireland). Department of Microbiology, 2001)A number of year ago workers in this laboratory identified antigen 43 (Ag43) during a systematic immunochemical analysis of the envelopes of Escherichia coli ML308-225 O13:O68:H . This Escherichia-specific outer membrane ... -
Molecular characterisation of Region A of FnBPA from Staphylococcus aureus
(Trinity College (Dublin, Ireland). Department of Microbiology, 2007)The surface-expressed fibronectin-binding proteins, FnBPA and FnBPB, of Staphylococcus aureus promote attachment to immobilised fibrinogen and elastin via the N-Terminal A region. The N2N3 subdomains of region A were found ... -
Molecular characterisation of the Salmonella-specific protein PagN
(Trinity College (Dublin, Ireland). Department of Microbiology, 2007)Salmonella infect a broad spectrum of animals resulting in host responses ranging from severe disease to asymptomatic carriage. Infection of a host gives rise to symptoms such as fever or self-limiting gastroenteritis. ... -
Molecular genetic typing characteristics of human and animal isolates of Staphylococcus aureus
(Trinity College (Dublin, Ireland). Department of Microbiology, 2009)Staphylococcus aureus is a commensal and an opportunistic pathogen of both man and animals. It is capable of causing a broad spectrum of diseases, ranging in severity from superficial skin complaints such as boils and ... -
Molecular genetic typing of Staphylococcus aureus from cows, goats, sheep, rabbits and chickens
(Trinity College (Dublin, Ireland). Department of Microbiology, 2006)Staphylococcus aureus is an important pathogen of man causing a range of infections from boils, carbuncles and abscesses to more serious and life-threatening infections like endocarditis and osteomyelitis. S. aureus is ... -
Platelet activation by Staphylococcus aureus
(Trinity College (Dublin, Ireland). Department of Microbiology, 2006)Staphylococcus aureus is the leading cause of infective endocarditis (IE). Platelet activation promoted by S. aureus resulting in aggregation and thrombus formation is thought to be an important step in the pathogenesis ... -
Preventing protein-dependent biofilm formation in Staphylococcus aureus by targeting the serine aspartate repeat protein C and fibronectin binding proteins
(Trinity College (Dublin, Ireland). Department of Microbiology, 2017)Staphylococcus aureus is a leading cause of biofilm infections on indwelling medical devices. S. aureus biofilm infections are intrinsically difficult to treat. They are recalcitrant to conventional antibiotics and resistant ... -
Recombinant vaccines against infectious pancreatic necrosis virus
(Trinity College (Dublin, Ireland). Department of Microbiology, 2000)The rapid expansion of the aquaculture industry in recent years has led to an increase in disease outbreaks. Over the last few years bacterial disease problems have been brought under control, largely due to the use of a ... -
Semliki Forest virus based gene therapy of rat glioma
(Trinity College (Dublin, Ireland). Department of Microbiology, 2009)Glioblastoma multiforme (GBM) is an invariably fatal neoplastic lesion of the CNS. Despite advances in the treatment of cancer in the recent years, the prognosis of GBM has changed little and patients who undergo surgical ... -
Sequence analysis of alphavirus pathogenesis
(Trinity College (Dublin, Ireland). Department of Microbiology, 2006)This investigation involved the sequencing and characterisation of Chikungunya virus (CHIKV), a positive-stranded RNA virus with a genome spanning 11.8 kb. The prototype strain of CHIKV, termed Ross was used. This is the ... -
Significance of the chromosomal positions of the genes encoding Integration Host Factor and DNA gyrase in Salmonella.
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2021)In this thesis, two studies are described that built upon the idea of the chromosomal gene importance. In both studies Salmonella was used as a model organism. In the first study, ihfA and ihfB ? genes that encode ... -
Structure-function analysis of the Fim-B and Fim-E site-specific recombinases of Escherichia coli K-12
(Trinity College (Dublin, Ireland). Department of Microbiology, 2006)Phase variable expression of type 1 fimbriae in Escherichia coli arises from a site-specific recombination event that inverts a 314 bp segment of chromosomal DNA (fimS) carrying the promoter for transcription of the gene ... -
Studies of Streptococcus pneumoniae colonisation : role of capsule and induction of protective immunity
(Trinity College (Dublin, Ireland). Department of Microbiology, 2010)Streptococcus pneumoniae (the pneumococcus) is a major human pathogen responsible for an estimated 1.6 million deaths each year, most of which are of young children in the developing world. Current pneumococcal vaccines ... -
Studies on clumping Factor A of Staphylococcus aureus
(Trinity College (Dublin, Ireland). Department of Microbiology, 2006)Clumping factor A is a fibrinogen-binding protein of S. aureus. It is a cell wall associated protein consisting of an N-terminal ligand-binding region A, an unusual SD dipeptide repeat region, which acts as a stalk to ... -
The cell biology of microtubule inhibition in Plasmodium falciparum
(Trinity College (Dublin, Ireland). Department of Microbiology, 2008)Malaria is among the most prevalent human infections worldwide and both the lack of a viable vaccine and the spread of resistance to commonly used drugs have limited the options for control of the parasite, especially ... -
The Dps protein of Salmonella enterica serovar Typhimurium
(Trinity College (Dublin, Ireland). Department of Microbiology, 2008)As a nucleoid-associated protein, Dps has long been thought to influence gene expression at a global level. In this study the role of Dps in genetic regulation in Salmonella enterica serovar Typhimurium was investigated. ... -
The genome of Plasmodium falciparum
(Trinity College (Dublin, Ireland). Department of Microbiology, 2007)The base distribution of the 14 nuclear chromsomes, of the plastid and the mitochondrion of the malarial parasite Plasmodium falciparum were studied. Isochores were discovered in the nuclear chromosomes and found to be ...
