Physiology (Theses and Dissertations): Recent submissions
Now showing items 21-40 of 108
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Evaluation of novel biomarkers in the detection of chemotherapy-mediated cardiac and kidney injury
(Trinity College (Dublin, Ireland). Department of Physiology, 2015)Chemotherapeutic agents are associated with a risk for potential cardiac and kidney injury, however diagnostic techniques currently used to assess cardiac function lack sensitivity, whilst those used to evaluate kidney ... -
Effects of high -intensity interval vs moderate-intensity continous training on the time course adapations in cardiovascular fitness and oxygen uptake kinetics in type 2 diabetes
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2019)Individuals with type 2 diabetes mellitus (T2DM) present with significant impairments in the dynamic and peak responses of pulmonary oxygen uptake (V̇O2) during exercise. Both low-volume high-intensity interval training ... -
Influence of hormonal status, ageing and smoking on autonomic cardiovascular control and endothelial function
(Trinity College (Dublin, Ireland). Department of Physiology, 2004)Ageing, hypertension and smoking are known risk factors for cardiovascular disease. By contrast female sex hormones are known to have cardioprotective qualities ; however, their underlying mechanisms of action have yet to ... -
Effects of acute and chronic exercise on autonomic cardiovascular control and endothelial function in young and older healthy male subjects
(Trinity College (Dublin, Ireland). Department of Physiology, 2002)Exercise training is known to reduce resting blood pressure ; however, the underlying mechanisms have yet to be fully elucidated. The main objective of this thesis was to investigate the effects of exercise in two parameters ... -
Characterisation of LTP induced by multiple spaced 200 Hz protocol in the rat dentate gyrus in vitro
(Trinity College (Dublin, Ireland). Department of Physiology, 2004)Long-term potentiation (LTP) in the hippocampus is believed to be a cellular correlate of learning and memory in the mammalian brain. Four different highfrequency stimulation (HFS) protocols were developed which induced ... -
A role for IL-1B in oxidative stress-mediated neuronal impairment
(Trinity College (Dublin, Ireland). Department of Physiology, 2000)The aims of this study were to; (1) investigate age-related changes in the antioxidant defence system in the rat cortex and hippocampus; (2) investigate the role of IL-1β in influencing oxidative stress in brain tissue of ... -
An investigation into the roles played by interleukin-1Beta and reactive oxygen species in the rat brain during ageing
(Trinity College (Dublin, Ireland). Department of Physiology, 2002)Ageing is associated with an increase in reactive oxygen species production and an increase in the concentration of the pro-inflammatory cytokine interleukin-1β in the hippocampus. These have both been shown to have ... -
The effects of group II mGluR agonists on short-term depression and neutral coding in the rat dentate gyrus in vitro
(Trinity College (Dublin, Ireland). Department of Physiology, 2000)Short-term depression is an activity-dependent reduction in synaptic efficacy which has been observed at a wide variety of synapses in the CNS, and is often attributed to a depletion of the available store of neurotransmitter. ... -
Mechanism of inhibition of LTP induction by preconditioning stimulation in the rat dentate gyrus in vitro
(Trinity College (Dublin, Ireland). Department of Physiology, 2003)The modulation of synaptic plasticity (LTP) by prior synaptic activity represented by preconditioning stimulation (weak HFS) was investigated in the medial perforant pathway of the dentate gyrus in vitro. The inhibition ... -
Endothelial physiology in young cigareete smokers : a multifunctional analysis of the effect of taurine supplementation
(Trinity College (Dublin, Ireland). Department of Physiology, 2000)The aim of this thesis is to determine the impact of cigarette smoking on endothelial dependent integration of the cardiovascular haemodynamic and barrier functions. Considering the antioxidant, anti-inflammatory and ... -
Investigating the role of mechanosensitive channel Piezo1 in the CNS
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2019)All cells in the organism are able to sense changes in the mechanical properties of their environment, translating them into chemical intracellular signals through a process termed mechanotransduction, mostly via ... -
A study of the role of neurotrophins in the mechanisms underlying the expression of long-term potentiation in the dentate gyrus
(Trinity College (Dublin, Ireland). Department of Physiology, 2002)Long-term potentiation (LTP) is a well-described form of synaptic plasticity. This study set out to investigate the role that tyrosine kinase plays in the expression of LTP at the perforant path-granule cell synapses of ... -
The role of Ca²+ and metabotropic glutamate receptors (mGluRs) in the induction of synaptic plasticity in the rat dentate gyrus in vitro
(Trinity College (Dublin, Ireland). Department of Physiology, 2000)This thesis is about the investigation of some properties of synaptic plasticity in the rat dentate gyrus in vitro. For the experiments brain slices were cut from unanaesthetized rats aged between 3 and 5 weeks. Extracellular ... -
An investigation into the effect of A beta on cultured cortical neurons
(Trinity College (Dublin, Ireland). Department of Physiology, 2003)Accumulation of the endogenously produced beta-amyloid (Aβ) peptide in senile plaques is involved in the development of Alzheimer’s disease. This study reports on potential molecular mechanisms underlying the cell death ... -
Effects of smoking and ageing on cardiovascular function
(Trinity College (Dublin, Ireland). Department of Physiology, 2004)Ageing and smoking have both been identified as important risk factors for cardiovascular morbidity and mortality. The aim of these studies was to investigate the effects of ageing and smoking on autonomic and endothelial ... -
Ischaemia-reperfusion-induced renal injury : pathogenesis & modulation implications for transplantation
(Trinity College (Dublin, Ireland). Department of Physiology, 2004)Ischaemia-reperfusion is unavoidable during transplantation, but may promote allograft rejection. Preconditioning with a sub-lethal stress protects cells against a subsequent otherwise lethal stress, possibly through the ... -
Effect of amyloid beta-peptide on synaptic plasticity in the Hippocampus in vitro
(Trinity College (Dublin, Ireland). Department of Physiology, 2005)Alzheimer's disease, the cause of one of the most common types of dementia, is a brain disorder affecting the elderly and is characterized by the formation of two main protein aggregates: senile plaques and neurofibrillary ... -
Analysis of the interaction between neurotrophins and cytokines with age
(Trinity College (Dublin, Ireland). Department of Physiology, 2004)Aging is associated with an increase in the concentration of the pro-inflammatory cytokine interleukin-1β in the hippocampus and cortex. This has been shown to have deleterious effects on the brain and specifically on a ... -
Influence of tensile strain on rat mesenchymal stem cell proliferation, differentiation and apoptosis
(Trinity College (Dublin, Ireland). Department of Physiology, 2008)Tissue engineering strategies that involve mesenchymal stem cells (MSCs) represent promising developments within regenerative medicine today. However, before MSCs are suitable for use in the clinic, the intricacies of how ... -
The effect of posture on muscle endurance, fatigue and blood flow
(Trinity College (Dublin, Ireland). Department of Physiology, 2005)Tilting the body from the supine to an upright position increases the time on a maximal graded cycle test by -1 5 % . However, this effect during constant-load cycling is unknown, and in addition, it is also unknown if ...
