Physiology (Theses and Dissertations): Recent submissions
Now showing items 41-60 of 108
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An investigation of the role of neurotrophins in recognition memory in the rat
(Trinity College (Dublin, Ireland). Department of Physiology, 2008)Acquisition and consolidation of newly-acquired information is essential for formation of long-lasting memories, and both these processes may share common signaling pathways. The neurotrophins NGF, BDNF, NTS and NT4 have ... -
An investigation of the role of c-Jun N-terminal Kinase (JNK) in inflammation-associated cell deterioration in rat hippocampus
(Trinity College (Dublin, Ireland). Department of Physiology, 2005)c-Jun N-terminal kinase (JNK) is a milogen-activated protein kinase which is activated in response to various types of stress (e.g. ischemia, heat shock, osmotic stress, UV irradiation, and hypoxia). JNK is strongly ... -
The effects of clozapine and haloperidol on astrocyte function and morphology
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2019)Schizophrenia is a chronic debilitating psychiatric disorder affecting approximately 1% of the population worldwide. The disorder is characterised by positive symptoms, negative symptoms, and clinical deficits in cognition. ... -
The role of GPR55 in neuronal and immune cell signalling and function
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2019)The orphan G-protein coupled receptor, GPR55, is widely expressed throughout the body and is responsive to cannabinoids. However, its endogenous ligand is believed to be L-a-lysophosphatidylinositol (LPI). GPR55 is expressed ... -
A study of transsynaptic signalling in the hippocampus : a role for nerve growth factor?
(Trinity College (Dublin, Ireland). Department of Physiology, 2001)Long-term potentiation (LTP) is perhaps the best described form of synaptic plasticity. This project aimed to investigate the role that tyrosine kinases play in the expression of LTP in dentate gyrus-granule cell synapses ... -
Exercise has persistent effects on learning and memory throught the lifespan: Analysis of the underlying mechanisms
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2018)Ageing is a complex process associated with a decline in organism functions. Ageing affects several cellular and molecular brain mechanisms and is commonly associated with decline in brain function, such as cognition and ... -
Investigating the role of fractalkine an S1P receptors on oxidative stress in the CNS
(Trinity College (Dublin, Ireland). Department of Physiology, 2016)Scientific Abstract: The fractalkine ligand (CX3CL1) is a unique chemokine that is synthesised as a transmembrane protein. One of the unique features of fractalkine is its ability to exist as both a membrane tethered ... -
An Investigation of Inflammatory and Metabolic Blood-Based Biomarkers of Cognitive Decline
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2018)Alzheimer’s disease (AD) and other dementias a re the main cause of cognitive impairment in older adults. AD is fast becoming a global epidemic, yet the development of a ... -
Pulmonary oxygen uptake and muscle deoxygenation responses during ramp incremental exercise and moderate- and heavy-intensity exercise subsequent to priming exercise in type 2 diabetes.
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2017)Middle-aged and young individuals with uncomplicated type 2 diabetes mellitus (T2DM) consistently demonstrate impairments in submaximal and maximal exercise performance, which are independent of obesity, and present in the ... -
The signalling and function of EB12 in the central nervous system
(Trinity College (Dublin, Ireland). Department of Physiology, 2014)The four major brain-specific cell types in the brain are; (i) neurons, which transmit and process information via electrical signals, (ii) oligodendrocytes, which insulate neuronal axons with fatty sheets called myelin ... -
The modulation of S1P receptor signalling and demyelination
(Trinity College (Dublin, Ireland). Department of Physiology, 2014)Sphingosine 1-phosphate receptors are a family of G-protein coupled receptors (GPCRs) that consists of five subtypes (S1PR1-5). These receptors have emerged as therapeutic targets in multiple sclerosis (MS) due to the ... -
Interactions between endocannabinoids and neurotrophins in adult neurogenesis : implications for spatial memory
(Trinity College (Dublin, Ireland). Department of Physiology, 2014)The cellular mechanisms underlying learning and memory have yet to be fully elucidated. Over the past fifteen years there has been a dramatic increase in the study of adult neurogenesis; a process in which neurons are ... -
Investigating the role of inflammation in schizophrenia
(Trinity College (Dublin, Ireland). Department of Physiology, 2013)Schizophrenia is a psychiatric illness that has more recently been described as a neurodevelopment disorder. The cause of this disorder is currently unknown and likely involves both genetic and environmental factors. Several ... -
Rodent models of immunologically induced-depression and anxiety related behaviour and associated biomarkers
(Trinity College (Dublin, Ireland). Department of Physiology, 2014)A series of rodent animal models of immune activation were assessed to develop an understanding of interactions between the immune system and brain leading to changes in behaviour and the determination of biomarkers of ... -
Neuroimmune activation in arthritic and neuropathic low back pain : implications for interventional therapies
(Trinity College (Dublin, Ireland). Department of Physiology, 2014)Chronic pain involves a progressive disturbance of mood, sleep and physical function, with significant medical, social and economic consequences. The mechanism by which acute pain may become chronic and refractory to ... -
An investigation of oxidative stress in skeletal muscle
(Trinity College (Dublin, Ireland). Department of Physiology, 2005)Reactive oxygen species (ROS) are produced as a by-product of oxidative phosphorylation in mitochondria and via various cellular enzyme systems. ROS production is buffered by cellular antioxidant defences, which include ... -
Beta₂-adrenoceptors as modulators of glial immune function
(Trinity College (Dublin, Ireland). Department of Physiology, 2009)The endogenous anti-inflammatory and neurotrophic effects of noradrenahne are mediated by β2-adrenoceptors on astrocytes and microglia in the central nervous system (CNS). Notably, clinical studies demonstrate that ... -
The effect of ageing and gender on calf vascular conductance and fatigue during plantar flexion excercise
(Trinity College (Dublin, Ireland). Department of Physiology, 2012)Background: Ageing is a complex multifaceted process, which ultimately results in a reduction in neuromuscular function and exercise tolerance. A reduced vasodilatory function and a slower rate of increase in blood flow ... -
Investigation into possible modulators of microglial activation
(Trinity College (Dublin, Ireland). Department of Physiology, 2010)Ageing is associated with an increase in inflammatory changes and a decline in biological function, inflammatory changes in the brain are primarily the result of activated microglia, the immune cells of the brain, and it ... -
Investigating the function of Sorting Nexin 8 and chemokines in Niemann Pick Type C disease
(Trinity College (Dublin, Ireland). Department of Physiology, 2013)It was shown that SNX8 (sorting nexin 8), a member of the sorting nexin super-family, plays a role In regulating the SREBP pathway (sterol regulatory element binding protein) of cholesterol homeostasis. Members of the SNX ...
